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Cardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study

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dc.contributor.author강석민-
dc.contributor.author김현창-
dc.date.accessioned2021-10-21T00:05:07Z-
dc.date.available2021-10-21T00:05:07Z-
dc.date.issued2021-10-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185368-
dc.description.abstractBackground: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in patients with cancer. However, the real-world CVD burden of adult cancer patients has not been well established. This study aimed to evaluate the prevalence and mortality of pre-existing and new-onset CVD in patients with cancers. Methods: We analysed the prevalence and mortality of pre-existing and new-onset CVD in 41,034 adult patients with ten common solid cancers in a single payer system using data from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Results: When all types of cancer were included, 11.3% (n = 4647) of patients had pre-existing CVD when they were diagnosed with cancer. After excluding patients with pre-existing CVD, 15.7% of cancer patients (n = 5703) were newly diagnosed with CVD during the follow-up period (median 68 months). Both pre-existing and new-onset CVD were associated with increased risk of overall mortality and 5-year mortality. Multivariate analysis to predict all-cause mortality indicated both pre-existing and new-onset CVD, male sex, old age, prior history of diabetes or chronic kidney disease, suburban residential area, and low-income status as significant factors. Conclusions: Eleven percent of cancer patients had pre-existing CVD at the time of cancer diagnosis, and about 16% of cancer patients without pre-existing CVD were newly diagnosed with CVD, mostly within 5 years after the cancer diagnosis. Proper management of pre-existing CVD is necessary and pre-emptive prevention of new-onset CVD may alter treatment options and outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHCardiovascular Diseases* / diagnosis-
dc.subject.MESHCardiovascular Diseases* / epidemiology-
dc.subject.MESHCohort Studies-
dc.subject.MESHDiabetes Mellitus*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNeoplasms* / diagnosis-
dc.subject.MESHNeoplasms* / epidemiology-
dc.subject.MESHPrevalence-
dc.subject.MESHRisk Factors-
dc.titleCardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJong-Chan Youn-
dc.contributor.googleauthorWoo-Baek Chung-
dc.contributor.googleauthorJustin A Ezekowitz-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorHyewon Nam-
dc.contributor.googleauthorDae-Sung Kyoung-
dc.contributor.googleauthorIn-Cheol Kim-
dc.contributor.googleauthorAlexander R Lyon-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorHae Ok Jung-
dc.contributor.googleauthorKiyuk Chang-
dc.contributor.googleauthorYong-Seog Oh-
dc.contributor.googleauthorHo-Joong Youn-
dc.contributor.googleauthorSang Hong Baek-
dc.contributor.googleauthorHyeon Chang Kim-
dc.identifier.doi10.1016/j.ijcard.2020.04.080-
dc.contributor.localIdA00037-
dc.contributor.localIdA01142-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid32360647-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0167527320302606-
dc.subject.keywordCancer-
dc.subject.keywordCardiovascular disease burden-
dc.subject.keywordMortality-
dc.subject.keywordPopulation-based cohort-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor김현창-
dc.citation.volume317-
dc.citation.startPage167-
dc.citation.endPage173-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.317 : 167-173, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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