18 46

Cited 0 times in

The Metabolic Score for Insulin Resistance (METS-IR) as a Predictor of Incident Ischemic Heart Disease: A Longitudinal Study among Korean without Diabetes

Authors
 Jihyun Yoon  ;  Donghyuk Jung  ;  Yongjae Lee  ;  Byoungjin Park 
Citation
 JOURNAL OF PERSONALIZED MEDICINE, Vol.11(8) : 742, 2021-07 
Journal Title
JOURNAL OF PERSONALIZED MEDICINE
Issue Date
2021-07
Keywords
metabolic score for insulin resistance ; cardiometabolic risk ; longitudinal study ; ischemic heart disease
Abstract
The metabolic score for insulin resistance (METS-IR) is a novel noninsulin-based marker for assessing the risk of insulin resistance and cardiometabolic risk. However, whether METS-IR is associated with incident ischemic heart disease (IHD) risk is not well known. Therefore, we aimed to investigate the longitudinal effect of METS-IR on incident IHD risk in a large cohort of Korean adults without diabetes. Data were assessed from 17,943 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to METS-IR index quartiles: (ln ((2 × fasting plasma glucose) + triglyceride) × body mass index)/(ln (HDL-cholesterol)). We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional hazard regression models over a 50-month period. During the follow-up period, 332 participants (1.9%) developed IHD. HRs of IHD for METS-IR quartiles 1–4 were 1.00, were 1.62 (95% CI 1.04–2.53), 1.87 (95% CI 1.20–2.91), and 2.11 (95% CI 1.35–3.30), respectively, after adjusting for potential confounding variables. A higher METS-IR precedes future IHD among Koreans without diabetes. Moreover, compared with metabolic syndrome, METS-IR had a better predictive value for IHD.
Files in This Item:
T202103394.pdf Download
DOI
10.3390/jpm11080742
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Yoon, Jihyun(윤지현) ORCID logo https://orcid.org/0000-0002-1057-2235
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184676
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links