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The effect of body fatness on regional brain imaging markers and cognitive function in healthy elderly mediated by impaired glucose metabolism

Authors
 Woojin Kim  ;  Heeseon Jang  ;  Yun Tae Kim  ;  Jaelim Cho  ;  Jungwoo Sohn  ;  Gayoung Seo  ;  Jiae Lee  ;  Sung Hee Yang  ;  Seung-Koo Lee  ;  Young Noh  ;  Sang-Baek Koh  ;  Sung Soo Oh  ;  Hee Jin Kim  ;  Sang Won Seo  ;  Ho Hyun Kim  ;  Jung Il Lee  ;  Sun-Young Kim  ;  Changsoo Kim 
Citation
 JOURNAL OF PSYCHIATRIC RESEARCH, Vol.140 : 488-495, 2021-08 
Journal Title
JOURNAL OF PSYCHIATRIC RESEARCH
ISSN
 0022-3956 
Issue Date
2021-08
MeSH
Aged ; Atrophy / pathology ; Brain* / diagnostic imaging ; Brain* / pathology ; Cognition ; Cognitive Dysfunction* / diagnostic imaging ; Cognitive Dysfunction* / etiology ; Cognitive Dysfunction* / pathology ; Cross-Sectional Studies ; Glucose ; Humans ; Magnetic Resonance Imaging ; Neuroimaging ; Neuropsychological Tests
Keywords
Body mass index ; Cerebral cortex ; Glucose metabolism disorders ; Hippocampus ; Magnetic resonance imaging
Abstract
Brain atrophy is related to vascular risk factors and can increase cognitive dysfunction risk. This community-based, cross-sectional study investigated whether glucose metabolic disorders due to body fatness are linked to regional changes in brain structure and a decline in neuropsychological function in cognitively healthy older adults. From 2016 to 2019, 429 participants underwent measurements for cortical thickness and subcortical volume using 3 T magnetic resonance imaging and for cognitive function using the neuropsychological screening battery. The effects of body fatness mediated by impaired glucose metabolism on neuroimaging markers and cognitive function was investigated using partial least square structural equation modeling. Total grey matter volume (β = -0.020; bias-corrected (BC) 95% confidence interval (CI) = -0.047 to -0.006), frontal (β = -0.029; BC 95% CI = -0.063 to -0.005) and temporal (β = -0.022; BC 95% CI = -0.051 to -0.004) lobe cortical thickness, and hippocampal volume (β = -0.029; BC 95% CI = -0.058 to -0.008) were indirectly related to body fatness. Further, frontal/temporal lobe thinning was associated with recognition memory (β = -0.005; BC 95% CI = -0.012 to -0.001/β = -0.005; BC 95% CI = -0.013 to -0.001) and delayed recall for visual information (β = -0.005; BC 95% CI = -0.013 to -0.001/β = -0.005; BC 95% CI = -0.013 to -0.001). Additionally, the smaller the hippocampal volume, the lower the score in recognition memory (β = -0.005; BC 95% CI = -0.012 to -0.001), delayed recall for visual information (β = -0.005; BC 95% CI = -0.012 to -0.001), and verbal learning (β = -0.008; BC 95% CI = -0.017 to -0.002). Our findings indicate that impaired glucose metabolism caused by excess body fatness affects memory decline as well as regional grey matter atrophy in elderly individuals with no neurological disease.
Full Text
https://www.sciencedirect.com/science/article/pii/S002239562100385X
DOI
10.1016/j.jpsychires.2021.06.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Woojin(김우진) ORCID logo https://orcid.org/0000-0001-5520-4228
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Cho, Jae Lim(조재림)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184467
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