Cited 4 times in
The effect of body fatness on regional brain imaging markers and cognitive function in healthy elderly mediated by impaired glucose metabolism
DC Field | Value | Language |
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dc.contributor.author | 김우진 | - |
dc.contributor.author | 김창수 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 조재림 | - |
dc.contributor.author | 장희선 | - |
dc.date.accessioned | 2021-09-29T01:37:49Z | - |
dc.date.available | 2021-09-29T01:37:49Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0022-3956 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184467 | - |
dc.description.abstract | Brain atrophy is related to vascular risk factors and can increase cognitive dysfunction risk. This community-based, cross-sectional study investigated whether glucose metabolic disorders due to body fatness are linked to regional changes in brain structure and a decline in neuropsychological function in cognitively healthy older adults. From 2016 to 2019, 429 participants underwent measurements for cortical thickness and subcortical volume using 3 T magnetic resonance imaging and for cognitive function using the neuropsychological screening battery. The effects of body fatness mediated by impaired glucose metabolism on neuroimaging markers and cognitive function was investigated using partial least square structural equation modeling. Total grey matter volume (β = -0.020; bias-corrected (BC) 95% confidence interval (CI) = -0.047 to -0.006), frontal (β = -0.029; BC 95% CI = -0.063 to -0.005) and temporal (β = -0.022; BC 95% CI = -0.051 to -0.004) lobe cortical thickness, and hippocampal volume (β = -0.029; BC 95% CI = -0.058 to -0.008) were indirectly related to body fatness. Further, frontal/temporal lobe thinning was associated with recognition memory (β = -0.005; BC 95% CI = -0.012 to -0.001/β = -0.005; BC 95% CI = -0.013 to -0.001) and delayed recall for visual information (β = -0.005; BC 95% CI = -0.013 to -0.001/β = -0.005; BC 95% CI = -0.013 to -0.001). Additionally, the smaller the hippocampal volume, the lower the score in recognition memory (β = -0.005; BC 95% CI = -0.012 to -0.001), delayed recall for visual information (β = -0.005; BC 95% CI = -0.012 to -0.001), and verbal learning (β = -0.008; BC 95% CI = -0.017 to -0.002). Our findings indicate that impaired glucose metabolism caused by excess body fatness affects memory decline as well as regional grey matter atrophy in elderly individuals with no neurological disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Pergamon Press | - |
dc.relation.isPartOf | JOURNAL OF PSYCHIATRIC RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrophy / pathology | - |
dc.subject.MESH | Brain* / diagnostic imaging | - |
dc.subject.MESH | Brain* / pathology | - |
dc.subject.MESH | Cognition | - |
dc.subject.MESH | Cognitive Dysfunction* / diagnostic imaging | - |
dc.subject.MESH | Cognitive Dysfunction* / etiology | - |
dc.subject.MESH | Cognitive Dysfunction* / pathology | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Glucose | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Neuroimaging | - |
dc.subject.MESH | Neuropsychological Tests | - |
dc.title | The effect of body fatness on regional brain imaging markers and cognitive function in healthy elderly mediated by impaired glucose metabolism | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Woojin Kim | - |
dc.contributor.googleauthor | Heeseon Jang | - |
dc.contributor.googleauthor | Yun Tae Kim | - |
dc.contributor.googleauthor | Jaelim Cho | - |
dc.contributor.googleauthor | Jungwoo Sohn | - |
dc.contributor.googleauthor | Gayoung Seo | - |
dc.contributor.googleauthor | Jiae Lee | - |
dc.contributor.googleauthor | Sung Hee Yang | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Young Noh | - |
dc.contributor.googleauthor | Sang-Baek Koh | - |
dc.contributor.googleauthor | Sung Soo Oh | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Sang Won Seo | - |
dc.contributor.googleauthor | Ho Hyun Kim | - |
dc.contributor.googleauthor | Jung Il Lee | - |
dc.contributor.googleauthor | Sun-Young Kim | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.identifier.doi | 10.1016/j.jpsychires.2021.06.011 | - |
dc.contributor.localId | A05662 | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A03895 | - |
dc.relation.journalcode | J01723 | - |
dc.identifier.eissn | 1879-1379 | - |
dc.identifier.pmid | 34153903 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S002239562100385X | - |
dc.subject.keyword | Body mass index | - |
dc.subject.keyword | Cerebral cortex | - |
dc.subject.keyword | Glucose metabolism disorders | - |
dc.subject.keyword | Hippocampus | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.contributor.alternativeName | Kim, Woojin | - |
dc.contributor.affiliatedAuthor | 김우진 | - |
dc.contributor.affiliatedAuthor | 김창수 | - |
dc.contributor.affiliatedAuthor | 이승구 | - |
dc.contributor.affiliatedAuthor | 조재림 | - |
dc.citation.volume | 140 | - |
dc.citation.startPage | 488 | - |
dc.citation.endPage | 495 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PSYCHIATRIC RESEARCH, Vol.140 : 488-495, 2021-08 | - |
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