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Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field

Authors
 Seung-Hyun Yang  ;  Byunghoon Kang  ;  Yuna Choi  ;  Hyun Wook Rho  ;  Hye Young Son  ;  Yong-Min Huh 
Citation
 NANOMEDICINE, Vol.16(10) : 787-800, 2021-04 
Journal Title
NANOMEDICINE
ISSN
 1743-5889 
Issue Date
2021-04
Keywords
Wnt/β-catenin signaling ; external magnetic field ; glioblastoma ; manganese ferrite magnetic nanoparticles ; tumor growth
Abstract
Aim: To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells. Methods: U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet in vitro and in vivo. Results: LRP6 and TCF7 mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments. Conclusion: When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/β-catenin signaling is increased and tumor growth is promoted.
Files in This Item:
T202102974.pdf Download
DOI
10.2217/nnm-2020-0399
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Son, Hye Yeong(손혜영) ORCID logo https://orcid.org/0000-0001-5977-6784
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184404
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