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Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field

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dc.contributor.author손혜영-
dc.contributor.author허용민-
dc.date.accessioned2021-09-29T01:30:44Z-
dc.date.available2021-09-29T01:30:44Z-
dc.date.issued2021-04-
dc.identifier.issn1743-5889-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184404-
dc.description.abstractAim: To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells. Methods: U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet in vitro and in vivo. Results: LRP6 and TCF7 mRNA levels involved in the Wnt/β-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments. Conclusion: When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/β-catenin signaling is increased and tumor growth is promoted.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFuture Medicine-
dc.relation.isPartOfNANOMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGenetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorSeung-Hyun Yang-
dc.contributor.googleauthorByunghoon Kang-
dc.contributor.googleauthorYuna Choi-
dc.contributor.googleauthorHyun Wook Rho-
dc.contributor.googleauthorHye Young Son-
dc.contributor.googleauthorYong-Min Huh-
dc.identifier.doi10.2217/nnm-2020-0399-
dc.contributor.localIdA04589-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ04084-
dc.identifier.eissn1748-6963-
dc.identifier.pmid33890494-
dc.subject.keywordWnt/β-catenin signaling-
dc.subject.keywordexternal magnetic field-
dc.subject.keywordglioblastoma-
dc.subject.keywordmanganese ferrite magnetic nanoparticles-
dc.subject.keywordtumor growth-
dc.contributor.alternativeNameSon, Hye Yeong-
dc.contributor.affiliatedAuthor손혜영-
dc.contributor.affiliatedAuthor허용민-
dc.citation.volume16-
dc.citation.number10-
dc.citation.startPage787-
dc.citation.endPage800-
dc.identifier.bibliographicCitationNANOMEDICINE, Vol.16(10) : 787-800, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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