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Active colorimetric lipid-coated polyaniline nanoparticles for redox state sensing in cancer cells

Authors
 Hwunjae Lee  ;  Hyun-Ouk Kim  ;  Hyun Soo Kim  ;  Ohwon Kwon  ;  Hyun-Wook Rho  ;  Yong-Min Huh  ;  Yoochan Hong 
Citation
 JOURNAL OF MATERIALS CHEMISTRY B, Vol.9(14) : 3131-3135, 2021-04 
Journal Title
JOURNAL OF MATERIALS CHEMISTRY B
ISSN
 2050-750X 
Issue Date
2021-04
Abstract
Herein, lipid-coated polyaniline (LiPAni) nanoparticles were fabricated to monitor the redox state of cancer cells. To confirm the characteristics of LiPAni, we firstly analyzed the size and chemical structures of the LiPAni nanoparticles. The absorbance properties of the LiPAni nanoparticles were observed to vary with the pH conditions. Furthermore, cell viability tests conducted with breast cancer cell lines showed that the cell viability of the cells with LiPAni nanoparticles was dramatically increased compared to those with the Tween80-coated polyaniline nanoparticles (TPAni) as a control. Subsequently, the colors of the LiPAni nanoparticles were observed and analyzed using spectroscopic methods. Finally, in order to investigate the more accurate sensing of the redox state using the color changes of the LiPAni nanoparticles with cancer cell lines, dark field microscopic images and scattering spectra were recorded at the single nanoparticle scale. For the TPAni nanoparticles, there was only a change in brightness and no change in color, but for the LiPAni nanoparticles, there was a change of color from yellow to pink in the dark field images.
Full Text
https://pubs.rsc.org/en/content/articlelanding/2021/TB/D1TB00058F#!divAbstract
DOI
10.1039/d1tb00058f
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hwun Jae(이훈재)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184115
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