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Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions

Authors
 Hyo-Jin Yoon  ;  Yong Jae Lee  ;  Sewoom Baek  ;  Young Shin Chung  ;  Dae-Hyun Kim  ;  Jae Hoon Lee  ;  Yong Cheol Shin  ;  Young Min Shin  ;  Chungsoon Ryu  ;  Hye-Seon Kim  ;  So Hyun Ahn  ;  Heeyon Kim  ;  Young Bin Won  ;  Inha Lee  ;  Myung Jae Jeon  ;  Si Hyun Cho  ;  Byung Seok Lee  ;  Hak-Joon Sung  ;  Young Sik Choi 
Citation
 SCIENCE ADVANCES, Vol.7(18) : eabe8873, 2021-04 
Journal Title
 SCIENCE ADVANCES 
Issue Date
2021-04
Abstract
The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.
Files in This Item:
T202101716.pdf Download
DOI
10.1126/sciadv.abe8873
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Dae-Hyun(김대현)
Kim, Heeyon(김희연)
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Shin, Young Min(신영민)
Ahn, So Hyun(안소현)
Won, Young Bin(원영빈) ORCID logo https://orcid.org/0000-0002-7345-7090
Yoon, Hyo-Jin(윤효진)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Lee, Yong Jae(이용재) ORCID logo https://orcid.org/0000-0003-0297-3116
Lee, Inha(이인하) ORCID logo https://orcid.org/0000-0003-4869-6281
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0003-4223-1395
Chung, Young Shin(정영신)
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182981
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