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Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions

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dc.contributor.author김대현-
dc.contributor.author김희연-
dc.contributor.author성학준-
dc.contributor.author신영민-
dc.contributor.author안소현-
dc.contributor.author원영빈-
dc.contributor.author윤효진-
dc.contributor.author이병석-
dc.contributor.author이용재-
dc.contributor.author이인하-
dc.contributor.author이재훈-
dc.contributor.author정영신-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.date.accessioned2021-05-26T17:04:46Z-
dc.date.available2021-05-26T17:04:46Z-
dc.date.issued2021-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182981-
dc.description.abstractThe regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAmerican Association for the Advancement of Science-
dc.relation.isPartOfSCIENCE ADVANCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorHyo-Jin Yoon-
dc.contributor.googleauthorYong Jae Lee-
dc.contributor.googleauthorSewoom Baek-
dc.contributor.googleauthorYoung Shin Chung-
dc.contributor.googleauthorDae-Hyun Kim-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorYong Cheol Shin-
dc.contributor.googleauthorYoung Min Shin-
dc.contributor.googleauthorChungsoon Ryu-
dc.contributor.googleauthorHye-Seon Kim-
dc.contributor.googleauthorSo Hyun Ahn-
dc.contributor.googleauthorHeeyon Kim-
dc.contributor.googleauthorYoung Bin Won-
dc.contributor.googleauthorInha Lee-
dc.contributor.googleauthorMyung Jae Jeon-
dc.contributor.googleauthorSi Hyun Cho-
dc.contributor.googleauthorByung Seok Lee-
dc.contributor.googleauthorHak-Joon Sung-
dc.contributor.googleauthorYoung Sik Choi-
dc.identifier.doi10.1126/sciadv.abe8873-
dc.contributor.localIdA04717-
dc.contributor.localIdA06072-
dc.contributor.localIdA01958-
dc.contributor.localIdA05925-
dc.contributor.localIdA05905-
dc.contributor.localIdA05484-
dc.contributor.localIdA06078-
dc.contributor.localIdA02795-
dc.contributor.localIdA05165-
dc.contributor.localIdA05497-
dc.contributor.localIdA04636-
dc.contributor.localIdA04849-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.relation.journalcodeJ03735-
dc.identifier.eissn2375-2548-
dc.identifier.pmid33910892-
dc.contributor.alternativeNameKim, Dae-Hyun-
dc.contributor.affiliatedAuthor김대현-
dc.contributor.affiliatedAuthor김희연-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor신영민-
dc.contributor.affiliatedAuthor안소현-
dc.contributor.affiliatedAuthor원영빈-
dc.contributor.affiliatedAuthor윤효진-
dc.contributor.affiliatedAuthor이병석-
dc.contributor.affiliatedAuthor이용재-
dc.contributor.affiliatedAuthor이인하-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor정영신-
dc.contributor.affiliatedAuthor조시현-
dc.contributor.affiliatedAuthor최영식-
dc.citation.volume7-
dc.citation.number18-
dc.citation.startPageeabe8873-
dc.identifier.bibliographicCitationSCIENCE ADVANCES, Vol.7(18) : eabe8873, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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