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Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions
DC Field | Value | Language |
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dc.contributor.author | 김대현 | - |
dc.contributor.author | 김희연 | - |
dc.contributor.author | 성학준 | - |
dc.contributor.author | 신영민 | - |
dc.contributor.author | 안소현 | - |
dc.contributor.author | 원영빈 | - |
dc.contributor.author | 윤효진 | - |
dc.contributor.author | 이병석 | - |
dc.contributor.author | 이용재 | - |
dc.contributor.author | 이인하 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 정영신 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2021-05-26T17:04:46Z | - |
dc.date.available | 2021-05-26T17:04:46Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182981 | - |
dc.description.abstract | The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isPartOf | SCIENCE ADVANCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Hyo-Jin Yoon | - |
dc.contributor.googleauthor | Yong Jae Lee | - |
dc.contributor.googleauthor | Sewoom Baek | - |
dc.contributor.googleauthor | Young Shin Chung | - |
dc.contributor.googleauthor | Dae-Hyun Kim | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Yong Cheol Shin | - |
dc.contributor.googleauthor | Young Min Shin | - |
dc.contributor.googleauthor | Chungsoon Ryu | - |
dc.contributor.googleauthor | Hye-Seon Kim | - |
dc.contributor.googleauthor | So Hyun Ahn | - |
dc.contributor.googleauthor | Heeyon Kim | - |
dc.contributor.googleauthor | Young Bin Won | - |
dc.contributor.googleauthor | Inha Lee | - |
dc.contributor.googleauthor | Myung Jae Jeon | - |
dc.contributor.googleauthor | Si Hyun Cho | - |
dc.contributor.googleauthor | Byung Seok Lee | - |
dc.contributor.googleauthor | Hak-Joon Sung | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.identifier.doi | 10.1126/sciadv.abe8873 | - |
dc.contributor.localId | A04717 | - |
dc.contributor.localId | A06072 | - |
dc.contributor.localId | A01958 | - |
dc.contributor.localId | A05925 | - |
dc.contributor.localId | A05905 | - |
dc.contributor.localId | A05484 | - |
dc.contributor.localId | A06078 | - |
dc.contributor.localId | A02795 | - |
dc.contributor.localId | A05165 | - |
dc.contributor.localId | A05497 | - |
dc.contributor.localId | A04636 | - |
dc.contributor.localId | A04849 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J03735 | - |
dc.identifier.eissn | 2375-2548 | - |
dc.identifier.pmid | 33910892 | - |
dc.contributor.alternativeName | Kim, Dae-Hyun | - |
dc.contributor.affiliatedAuthor | 김대현 | - |
dc.contributor.affiliatedAuthor | 김희연 | - |
dc.contributor.affiliatedAuthor | 성학준 | - |
dc.contributor.affiliatedAuthor | 신영민 | - |
dc.contributor.affiliatedAuthor | 안소현 | - |
dc.contributor.affiliatedAuthor | 원영빈 | - |
dc.contributor.affiliatedAuthor | 윤효진 | - |
dc.contributor.affiliatedAuthor | 이병석 | - |
dc.contributor.affiliatedAuthor | 이용재 | - |
dc.contributor.affiliatedAuthor | 이인하 | - |
dc.contributor.affiliatedAuthor | 이재훈 | - |
dc.contributor.affiliatedAuthor | 정영신 | - |
dc.contributor.affiliatedAuthor | 조시현 | - |
dc.contributor.affiliatedAuthor | 최영식 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | eabe8873 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, Vol.7(18) : eabe8873, 2021-04 | - |
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