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High-resolution T 1 MRI via renally clearable dextran nanoparticles with an iron oxide shell

Authors
 Tae-Hyun Shin  ;  Pan Ki Kim  ;  Sunghwi Kang  ;  Jiyong Cheong  ;  Soojin Kim  ;  Yongjun Lim  ;  Wookjin Shin  ;  Joon-Yong Jung  ;  Jungsu D Lah  ;  Byoung Wook Choi  ;  Jinwoo Cheon 
Citation
 NATURE BIOMEDICAL ENGINEERING, Vol.5(3) : 252-263, 2021-03 
Journal Title
 NATURE BIOMEDICAL ENGINEERING 
Issue Date
2021-03
MeSH
Animals ; Biocompatible Materials / chemistry ; Contrast Media / chemistry ; Dextrans / chemistry* ; Ferric Compounds / chemistry* ; Gadolinium / chemistry ; Magnetic Resonance Imaging / methods* ; Meglumine / chemistry ; Mice ; Mice, Inbred BALB C ; Microvessels / pathology ; Nanoparticles / chemistry* ; Organometallic Compounds / chemistry ; Particle Size ; Polysaccharides / chemistry ; Rabbits ; Rats ; Rats, Sprague-Dawley
Abstract
Contrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owing to poor image resolution in whole-body MRI, resolving fine structures is challenging. Here, we report that a nanoparticle with a polysaccharide supramolecular core and a shell of amorphous-like hydrous ferric oxide generating strong T1 MRI contrast (with a relaxivity coefficient ratio of ~1.2) facilitates the imaging, at resolutions of the order of a few hundred micrometres, of cerebral, coronary and peripheral microvessels in rodents and of lower-extremity vessels in rabbits. The nanoparticle can be synthesized at room temperature in aqueous solution and in the absence of surfactants, has blood circulation and renal clearance profiles that prevent opsonization, and leads to better imaging performance than Dotarem (gadoterate meglumine), a clinically approved gadolinium-based MRI contrast agent. The nanoparticle's biocompatibility and imaging performance may prove advantageous in a broad range of preclinical and clinical applications of MRI.
Full Text
https://www.nature.com/articles/s41551-021-00687-z
DOI
10.1038/s41551-021-00687-z
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Tae-Hyun(신태현)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182953
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