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Leukocyte count, C-reactive protein level and incidence risk of type 2 diabetes among non-smoking adults: A longitudinal finding over 12 years from the Korean Genome and Epidemiology Study

Authors
 A-Ra Cho  ;  Jun-Hyuk Lee  ;  Hye Sun Lee  ;  Yong-Jae Lee 
Citation
 PRIMARY CARE DIABETES, Vol.15(2) : 385-390, 2021-04 
Journal Title
 PRIMARY CARE DIABETES 
ISSN
 1751-9918 
Issue Date
2021-04
Keywords
C-Reactive protein ; Leukocyte count ; Type 2 diabetes mellitus
Abstract
Aims: Chronic low-grade inflammation is closely linked to the development and progression of type 2 diabetes mellitus (T2DM). Since inflammatory markers tend to be chronically elevated in current smokers, we examined the association of inflammatory markers, including leukocyte counts and C-reactive protein (CRP) levels, with incidence risk of T2DM in non-smoking adults. Methods: 5568 non-smoking participants aged 40-69 years without diabetes at baseline were selected from the Korean Genome and Epidemiology Study (KoGES), a large prospective cohort study. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident T2DM according to leukocyte and CRP quartiles, respectively, were calculated using multivariate Cox proportional hazards regression models. Results: During the 12-year follow-up period, T2DM developed in 1030 subjects (18.5%, 1030/5568), with an incidence rate of 3.1-4.9 per 2 years. The cumulative incidence of T2DM increased proportionally with increasing leukocyte and CRP quartiles. Compared with the reference first quartile, the HRs of incident T2DM in the second, third, and fourth quartiles of leukocyte counts and third and fourth quartiles of CRP levels increased in a dose-dependent manner after adjusting for potentially confounding variables. Conclusions: Leukocyte counts and CRP levels are predictors of incident T2DM independent of tobacco smoking.
Full Text
https://www.sciencedirect.com/science/article/pii/S1751991820303260
DOI
10.1016/j.pcd.2020.11.010
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Jun-Hyuk(이준혁) ORCID logo https://orcid.org/0000-0002-1007-1633
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, A Ra(조아라) ORCID logo https://orcid.org/0000-0002-3645-2282
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182226
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