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Initial experience of irreversible electroporation for locally advanced pancreatic cancer in a Korean population

Authors
 Joon Ho Kwon  ;  Moon Jae Chung  ;  Jeong Youp Park  ;  Hee Seung Lee  ;  Ho Kyoung Hwang  ;  Chang Moo Kang  ;  Woo Jung Lee  ;  Mi-Suk Park  ;  Namo Kim  ;  Seungmin Bang  ;  Man-Deuk Kim 
Citation
 ACTA RADIOLOGICA, Vol.62(2) : 164-171, 2021-02 
Journal Title
 ACTA RADIOLOGICA 
ISSN
 0284-1851 
Issue Date
2021-02
MeSH
Aged ; Electroporation / methods* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Pancreas / enzymology ; Pancreatic Neoplasms / blood ; Pancreatic Neoplasms / enzymology ; Pancreatic Neoplasms / therapy* ; Republic of Korea ; Survival Analysis ; Treatment Outcome
Keywords
Locally advanced pancreatic cancer ; clinical outcomes ; complications ; irreversible electroporation
Abstract
Background: Locally advanced pancreatic cancer (LAPC) is one of the most aggressive malignancies. Irreversible electroporation (IRE) is a novel technique that uses a non-thermal ablation to avoid vessel or duct injury. Purpose: To investigate the safety and efficacy of IRE for the management of LAPC in a Korean population. Material and methods: Twelve patients (median age 64 years; age range 46-73 years) treated between December 2015 and March 2017 underwent intraoperative IRE for LAPC. Technical success and clinical outcomes, including complications, serum pancreatic enzyme levels, overall survival (OS), and progression-free survival (PFS), were evaluated. Results: Tumors were located in the pancreas head in 7 (58.3%) patients and in the body/tail in 5 (41.7%) patients. The median tumor diameter in the longest axis was 3.1 cm. Vascular invasion was observed in all patients and bowel abutment in 3 (25%) patients. Technical success was achieved in all patients. The median serum levels of amylase and lipase were 55 U/L and 31 U/L, respectively, at baseline, increased to 141.5 U/L (P = 0.008) and 53 U/L (P = 0.505), respectively, one day after IRE, and normalized after one week. The rate of 30-day mortality of unknown relation was 8.3% (one individual experienced massive hematemesis 12 days after IRE). The median OS from diagnosis and IRE was 24.5 months and 13.5 months, respectively. The median PFS from diagnosis and IRE was 19.2 months and 8.6 months, respectively. Conclusion: For patients with LAPC, IRE appears to be a promising treatment modality with an acceptable safety profile.
Full Text
https://journals.sagepub.com/doi/10.1177/0284185120917118
DOI
10.1177/0284185120917118
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kwon, Joon Ho(권준호) ORCID logo https://orcid.org/0000-0002-6178-7252
Kim, Namo(김남오) ORCID logo https://orcid.org/0000-0002-0829-490X
Kim, Man Deuk(김만득) ORCID logo https://orcid.org/0000-0002-3575-5847
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Park, Jeong Youp(박정엽) ORCID logo https://orcid.org/0000-0003-0110-8606
Bang, Seungmin(방승민) ORCID logo https://orcid.org/0000-0001-5209-8351
Lee, Woo Jung(이우정) ORCID logo https://orcid.org/0000-0001-9273-261X
Lee, Hee Seung(이희승) ORCID logo https://orcid.org/0000-0002-2825-3160
Chung, Moon Jae(정문재) ORCID logo https://orcid.org/0000-0002-5920-8549
Hwang, Ho Kyoung(황호경) ORCID logo https://orcid.org/0000-0003-4064-7776
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182108
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