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Initial experience of irreversible electroporation for locally advanced pancreatic cancer in a Korean population

DC Field Value Language
dc.contributor.author강창무-
dc.contributor.author권준호-
dc.contributor.author김남오-
dc.contributor.author김만득-
dc.contributor.author박미숙-
dc.contributor.author박정엽-
dc.contributor.author방승민-
dc.contributor.author이우정-
dc.contributor.author이희승-
dc.contributor.author정문재-
dc.contributor.author황호경-
dc.date.accessioned2021-04-29T16:57:39Z-
dc.date.available2021-04-29T16:57:39Z-
dc.date.issued2021-02-
dc.identifier.issn0284-1851-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182108-
dc.description.abstractBackground: Locally advanced pancreatic cancer (LAPC) is one of the most aggressive malignancies. Irreversible electroporation (IRE) is a novel technique that uses a non-thermal ablation to avoid vessel or duct injury. Purpose: To investigate the safety and efficacy of IRE for the management of LAPC in a Korean population. Material and methods: Twelve patients (median age 64 years; age range 46-73 years) treated between December 2015 and March 2017 underwent intraoperative IRE for LAPC. Technical success and clinical outcomes, including complications, serum pancreatic enzyme levels, overall survival (OS), and progression-free survival (PFS), were evaluated. Results: Tumors were located in the pancreas head in 7 (58.3%) patients and in the body/tail in 5 (41.7%) patients. The median tumor diameter in the longest axis was 3.1 cm. Vascular invasion was observed in all patients and bowel abutment in 3 (25%) patients. Technical success was achieved in all patients. The median serum levels of amylase and lipase were 55 U/L and 31 U/L, respectively, at baseline, increased to 141.5 U/L (P = 0.008) and 53 U/L (P = 0.505), respectively, one day after IRE, and normalized after one week. The rate of 30-day mortality of unknown relation was 8.3% (one individual experienced massive hematemesis 12 days after IRE). The median OS from diagnosis and IRE was 24.5 months and 13.5 months, respectively. The median PFS from diagnosis and IRE was 19.2 months and 8.6 months, respectively. Conclusion: For patients with LAPC, IRE appears to be a promising treatment modality with an acceptable safety profile.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSage-
dc.relation.isPartOfACTA RADIOLOGICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHElectroporation / methods*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPancreas / enzymology-
dc.subject.MESHPancreatic Neoplasms / blood-
dc.subject.MESHPancreatic Neoplasms / enzymology-
dc.subject.MESHPancreatic Neoplasms / therapy*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleInitial experience of irreversible electroporation for locally advanced pancreatic cancer in a Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorJoon Ho Kwon-
dc.contributor.googleauthorMoon Jae Chung-
dc.contributor.googleauthorJeong Youp Park-
dc.contributor.googleauthorHee Seung Lee-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorNamo Kim-
dc.contributor.googleauthorSeungmin Bang-
dc.contributor.googleauthorMan-Deuk Kim-
dc.identifier.doi10.1177/0284185120917118-
dc.contributor.localIdA00088-
dc.contributor.localIdA05085-
dc.contributor.localIdA00356-
dc.contributor.localIdA00420-
dc.contributor.localIdA01463-
dc.contributor.localIdA01647-
dc.contributor.localIdA01786-
dc.contributor.localIdA02993-
dc.contributor.localIdA03349-
dc.contributor.localIdA03602-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ00033-
dc.identifier.eissn1600-0455-
dc.identifier.pmid32295390-
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1177/0284185120917118-
dc.subject.keywordLocally advanced pancreatic cancer-
dc.subject.keywordclinical outcomes-
dc.subject.keywordcomplications-
dc.subject.keywordirreversible electroporation-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthor강창무-
dc.contributor.affiliatedAuthor권준호-
dc.contributor.affiliatedAuthor김남오-
dc.contributor.affiliatedAuthor김만득-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor박정엽-
dc.contributor.affiliatedAuthor방승민-
dc.contributor.affiliatedAuthor이우정-
dc.contributor.affiliatedAuthor이희승-
dc.contributor.affiliatedAuthor정문재-
dc.contributor.affiliatedAuthor황호경-
dc.citation.volume62-
dc.citation.number2-
dc.citation.startPage164-
dc.citation.endPage171-
dc.identifier.bibliographicCitationACTA RADIOLOGICA, Vol.62(2) : 164-171, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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