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Heterophile antibody interference associated with natural killer cell therapy

 Daham Kim  ;  Namki Hong  ;  Yonggeun Cho  ;  Sang-Guk Lee  ;  Yumie Rhee 
 ENDOCRINE JOURNAL, Vol.67(12) : 1187-1192, 2020-12 
Journal Title
Issue Date
Heterophile antibody ; Natural killer cell ; Parathyroid hormone ; Thyroglobulin
The adoptive transfer of ex vivo-expanded natural killer (NK) cells has recently been employed as an alternative cancer treatment in certain institutions. However, the safety profiles of this strategy remain uncharacterized. We evaluated three patients who exhibited elevated serum parathyroid hormone (PTH) levels without the relevant clinical manifestations and had a history of autologous NK cell therapy. The serum PTH concentration was measured using a second-generation PTH assay, and the serum thyroglobulin concentration was measured using a second-generation thyroglobulin assay. Subsequently, the PTH or thyroglobulin concentration obtained using heterophile-blocking tube (HBT) for a secondary confirmation assay was measured and compared with the result of the initial assay. The three patients had falsely elevated serum PTH and thyroglobulin levels owing to heterophile antibody interference associated with NK cell therapy that persisted for at least up to 12 months after the treatment and was confirmed by normalization of hormone levels after HBT treatment. We propose that certain types of mouse monoclonal antibodies used to stimulate NK cells can induce heterophile antibodies. Abnormal laboratory test results in individuals administered NK cell therapy without the relevant clinical manifestations must be examined in the context of heterophile antibody interference to avoid misdiagnosis and unnecessary testing.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Daham(김다함) ORCID logo https://orcid.org/0000-0003-1871-686X
Lee, Sang-Guk(이상국) ORCID logo https://orcid.org/0000-0003-3862-3660
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
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