15 23

Cited 0 times in

Additive prognostic value of red cell distribution width over late gadolinium enhancement on CMR in patients with non-ischemic dilated cardiomyopathy

 Jeong-Eun Yi  ;  Hye-Jeong Lee  ;  Young Jin Kim  ;  Yookyung Kim  ;  Boyoung Joung  ;  Junbeom Park 
 SCIENTIFIC REPORTS, Vol.10(1) : 9212, 2020-06 
Journal Title
Issue Date
Cardiomyopathy, Dilated / pathology* ; Contrast Media / administration & dosage ; Death, Sudden, Cardiac / pathology ; Erythrocyte Indices / physiology* ; Erythrocytes / physiology* ; Female ; Follow-Up Studies ; Gadolinium / administration & dosage* ; Heart Failure / pathology ; Humans ; Magnetic Resonance Imaging, Cine / methods ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Republic of Korea ; Retrospective Studies ; Risk Factors ; Stroke Volume / physiology ; Ventricular Dysfunction, Left / pathology ; Ventricular Function, Left / physiology
Elevated red cell distribution width (RDW) and late gadolinium enhancement on cardiac magnetic resonance (LGE-CMR) are both poor prognostic factors. This study examined the relationship between RDW and LGE-CMR characteristics in patients with non-ischemic dilated cardiomyopathy (NICM), and investigated whether the additive prognostic value of RDW as an integrative systemic factor over LGE-CMR exists or not. A total of consecutive 378 patients who underwent CMR at two general hospitals in South Korea were retrospectively analyzed. The primary endpoint was a composite of all-cause death, hospitalizations due to worsening heart failure and major arrhythmic events. During a mean follow-up period of 40.8 months, 151 (39.9%) patients experienced primary endpoints. The RDW value was significantly higher in patients with LGE than in those without LGE (13.7 ± 1.5% vs. 13.3 ± 1.4%, p = 0.034), but it was not associated with the extent or distribution patterns of the LGE. Addition of RDW into the model with clinical risk factors and LGE-CMR characteristics led to a significant improvement in the prediction of worse outcomes (χ2 increased from 73 to 82; p = 0.023). RDW could provide incremental predictive value for adverse clinical events beyond LGE-CMR data in NICM patients.
Files in This Item:
T202005944.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.