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A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2

Authors
 Ji Hyun Park  ;  Yoon Jin Cha  ;  Jong Hee Chang  ;  Seung-Koo Lee  ;  Se Hoon Kim 
Citation
 BRAIN TUMOR PATHOLOGY, Vol.37(3) : 95-99, 2020-07 
Journal Title
 BRAIN TUMOR PATHOLOGY 
ISSN
 1433-7398 
Issue Date
2020-07
MeSH
Adult ; Antigens, CD34 ; Brain Neoplasms / diagnosis* ; Brain Neoplasms / pathology* ; Frontal Lobe / diagnostic imaging ; Frontal Lobe / pathology ; Humans ; Isocitrate Dehydrogenase / genetics ; Magnetic Resonance Imaging ; Male ; Mutation ; Oligodendroglioma / diagnosis* ; Oligodendroglioma / pathology*
Keywords
Fluorescence in situ hybridization ; Ganglioglioma ; Immunohistochemistry ; Neurocytic differentiation ; Oligodendroglioma
Abstract
We report a rare case of oligodendroglioma with gangliocytic differentiation. A 31-year-old male without a past medical history was admitted with a sudden seizure. On magnetic resonance imaging, an approximately 7-cm mass with necrosis was noted in the right frontal lobe. The patient underwent surgical resection. On microscopy, two morphologically distinct areas with oligodendroglioma- and ganglioglioma-like features were found. Immunohistochemistry showed an absence of CD34 expression, whereas isocitrate dehydrogenase 1 (IDH1) was positive in the glial component. Moreover, IDH1 was positive in the ganglion-like cells as well as in the glial component. Subsequent 1p/19q co-deletion was confirmed by fluorescence in situ hybridization. Finally, a diagnosis of oligodendroglioma with gangliocytic differentiation was made. IDH1/2 molecular test would be basic and essential diagnostic tool in central nervous system tumor of young patients.
Full Text
https://link.springer.com/article/10.1007%2Fs10014-020-00368-w
DOI
10.1007/s10014-020-00368-w
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179559
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