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A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2
DC Field | Value | Language |
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dc.contributor.author | 장종희 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 차윤진 | - |
dc.contributor.author | 이승구 | - |
dc.date.accessioned | 2020-09-29T06:26:20Z | - |
dc.date.available | 2020-09-29T06:26:20Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1433-7398 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179559 | - |
dc.description.abstract | We report a rare case of oligodendroglioma with gangliocytic differentiation. A 31-year-old male without a past medical history was admitted with a sudden seizure. On magnetic resonance imaging, an approximately 7-cm mass with necrosis was noted in the right frontal lobe. The patient underwent surgical resection. On microscopy, two morphologically distinct areas with oligodendroglioma- and ganglioglioma-like features were found. Immunohistochemistry showed an absence of CD34 expression, whereas isocitrate dehydrogenase 1 (IDH1) was positive in the glial component. Moreover, IDH1 was positive in the ganglion-like cells as well as in the glial component. Subsequent 1p/19q co-deletion was confirmed by fluorescence in situ hybridization. Finally, a diagnosis of oligodendroglioma with gangliocytic differentiation was made. IDH1/2 molecular test would be basic and essential diagnostic tool in central nervous system tumor of young patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag Tokyo | - |
dc.relation.isPartOf | BRAIN TUMOR PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antigens, CD34 | - |
dc.subject.MESH | Brain Neoplasms / diagnosis* | - |
dc.subject.MESH | Brain Neoplasms / pathology* | - |
dc.subject.MESH | Frontal Lobe / diagnostic imaging | - |
dc.subject.MESH | Frontal Lobe / pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isocitrate Dehydrogenase / genetics | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Oligodendroglioma / diagnosis* | - |
dc.subject.MESH | Oligodendroglioma / pathology* | - |
dc.title | A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | Ji Hyun Park | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.identifier.doi | 10.1007/s10014-020-00368-w | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A04001 | - |
dc.contributor.localId | A02912 | - |
dc.relation.journalcode | J00397 | - |
dc.identifier.eissn | 1861-387X | - |
dc.identifier.pmid | 32504153 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10014-020-00368-w | - |
dc.subject.keyword | Fluorescence in situ hybridization | - |
dc.subject.keyword | Ganglioglioma | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Neurocytic differentiation | - |
dc.subject.keyword | Oligodendroglioma | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | 장종희 | - |
dc.contributor.affiliatedAuthor | 김세훈 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.contributor.affiliatedAuthor | 이승구 | - |
dc.citation.volume | 37 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 99 | - |
dc.identifier.bibliographicCitation | BRAIN TUMOR PATHOLOGY, Vol.37(3) : 95-99, 2020-07 | - |
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