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Study of the Drying Kinetics of a Hyaluronic Acid Pellet by Using Terahertz Time-Domain Spectroscopy

Authors
 Hee Jun Shin  ;  Jae Hun Park  ;  Eun-Kyung Lim  ;  Hyeung Mun Kim  ;  Young-Min Huh  ;  Seung Jae Oh  ;  Youngbin Ji  ;  Han-Cheol Ryu 
Citation
 JOURNAL OF THE KOREAN PHYSICAL SOCIETY, Vol.75(11) : 895-898, 2019-12 
Journal Title
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
ISSN
 0374-4884 
Issue Date
2019-12
Keywords
Terahertz ; Time-domain spectroscopy ; Refractive index ; Absorption coefficient ; Moisture
Abstract
We measured the moisture content of a hyaluronic acid (HA) pellet by using terahertz time-domain spectroscopy (THz-TDS). The drying dynamics of the HA pellet was investigated using THz-TDS for a 48-h period. During the measurement time, the THz time-domain waveforms of the HA pellet were measured 400 times in a dehydrated chamber, and the refractive index and the absorption coefficient were extracted based on the terahertz signals. The refractive index and the absorption coefficient of the HA pellet were shown to decrease rapidly during the first 4 h and to decrease slowly after 24 h. In addition, the drying kinetics of the HA pellet within the terahertz frequency range was clearly analyzed using a double-exponential fitting model because the measurement of such kinetics demonstrates both fast and slow damping dynamics. The results indicate that the drying kinetics of the HA pellet was successfully analyzed using THz-TDS through a non-contact and non-destructive investigation method and that the THz-TDS can be applied to a study of the drying kinetics of various products, such as foods, cosmetics, and pharmaceuticals.
Full Text
https://link.springer.com/article/10.3938%2Fjkps.75.895
DOI
10.3938/jkps.75.895
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Seung Jae(오승재)
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178103
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