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Technetium-99m-ECD brain SPECT in cerebral palsy: comparison with MRI
DC Field | Value | Language |
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dc.contributor.author | 김동구 | - |
dc.contributor.author | 김동익 | - |
dc.contributor.author | 박창일 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이종두 | - |
dc.date.accessioned | 2020-07-02T18:10:03Z | - |
dc.date.available | 2020-07-02T18:10:03Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177204 | - |
dc.description.abstract | Hypoxic brain injury is one of the major causes of cerebral palsy. Therefore, this study was performed to evaluate cerebral perfusion impairments in these patients using 99mTc-ECD brain SPECT. METHODS: Fifty-one patients (31 boys, 20 girls; age range 6 mo to 6 yr, 11 mo) with clinical manifestations of cerebral palsy underwent brain SPECT after intravenous injection of 99mTc-ECD. The clinical subtypes of cerebral palsy were spastic diplegia (n = 35), spastic quadriplegia (n = 11), spastic hemiparesis (n = 2), choreoathetoid (n = 2) and mixed (n = 1). Transaxial, coronal and sagittal images obtained with a brain-dedicated annular crystal gamma camera were qualitatively analyzed and compared with the findings of magnetic resonance imaging (MRI). RESULTS: In SPECT, thalamic hypoperfusion was seen in all patients except one (98%), followed by hypoperfusion in the temporal lobe (52.9%, n = 27), basal ganglia (41.2%, n = 21), cerebellum (39.2%, n = 20) and extratemporal cortices (21.6%, n = 11). However, MR imaging demonstrated thalamic abnormality in seven (13.7%), basal ganglia in two (3.9%), extratemporal cortical defect in five (9.8%) and cerebellar atrophy in one (1.9%). Instead, white matter changes such as periventricular leukomalacia or ischemia (56.9%, n = 25) and thinning of corpus callosum (49%, n = 25) were the major findings. CONCLUSION: Brain SPECT is useful in the diagnosis of cerebral palsy and is more sensitive in the detection of cortical, subcortical nuclei and cerebellar abnormalities. MRI is superior in the detection of white matter changes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Society of Nuclear Medicine | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Brain/diagnostic imaging* | - |
dc.subject.MESH | Brain/pathology | - |
dc.subject.MESH | Cerebral Palsy/diagnostic imaging* | - |
dc.subject.MESH | Cerebral Palsy/pathology | - |
dc.subject.MESH | Cerebrovascular Circulation* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cysteine/analogs & derivatives* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Magnetic Resonance Imaging* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Organotechnetium Compounds* | - |
dc.subject.MESH | Radiopharmaceuticals* | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon* | - |
dc.title | Technetium-99m-ECD brain SPECT in cerebral palsy: comparison with MRI | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Dong Ik Kim | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Geum Ju Whang | - |
dc.contributor.googleauthor | Chang II Park | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.contributor.localId | A00396 | - |
dc.contributor.localId | A00408 | - |
dc.contributor.localId | A01717 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A03138 | - |
dc.relation.journalcode | J01644 | - |
dc.identifier.eissn | 1535-5667 | - |
dc.identifier.pmid | 9544666 | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | 김동구 | - |
dc.contributor.affiliatedAuthor | 김동익 | - |
dc.contributor.affiliatedAuthor | 박창일 | - |
dc.contributor.affiliatedAuthor | 유영훈 | - |
dc.contributor.affiliatedAuthor | 이종두 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 619 | - |
dc.citation.endPage | 623 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, Vol.39(4) : 619-623, 1998 | - |
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