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Expression of Fas-related genes in human hepatocellular carcinomas

Authors
 Eui-Cheol Shin  ;  Jeon-Soo Shin  ;  Jeon Han Park  ;  Jeong-Jhin Kim  ;  Hoguen Kim  ;  Se Jong Kim 
Citation
 CANCER LETTERS, Vol.134(2) : 155-162, 1998 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1998
MeSH
Apoptosis/genetics* ; Carcinoma, Hepatocellular/genetics* ; Carcinoma, Hepatocellular/virology ; Down-Regulation ; Flow Cytometry ; Fluorescent Antibody Technique ; Gene Expression Regulation, Neoplastic* ; Hepatitis B/complications ; Humans ; Liver Neoplasms/genetics* ; Liver Neoplasms/virology ; Proto-Oncogene Proteins/genetics* ; RNA, Messenger/analysis ; RNA, Neoplasm/analysis ; Tumor Cells, Cultured ; Up-Regulation
Abstract
Hepatocellular carcinoma (HCC) is one of the tumors known to be resistant to Fas-mediated apoptosis. To elucidate the possible mechanisms of this resistance, we examined the mRNA transcripts of genes related to Fas in 10 hepatitis B virus (HBV)-associated HCC cell lines and six HBV-associated HCC tissues. Most of the HBV-associated HCC cell lines showed markedly decreased Fas expression. Some cell lines expressed FAP, a possible inhibitor of apoptosis, or showed downregulated expression of FADD or FLICE, molecules essential to Fas-mediated apoptosis. All six HBV-associated HCC tissues also showed decreased Fas expression compared with their non-malignant counterparts. Our data demonstrate that HBV-associated HCC showed a common defect in the expression of Fas, upregulation of FAP and downregulation of downstream molecules such as FADD and FLICE.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383598002511
DOI
10.1016/s0304-3835(98)00251-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Kim, Hogeun(김호근)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176828
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