Cited 40 times in
Expression of Fas-related genes in human hepatocellular carcinomas
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 신전수 | - |
dc.date.accessioned | 2020-07-02T17:28:04Z | - |
dc.date.available | 2020-07-02T17:28:04Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176828 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the tumors known to be resistant to Fas-mediated apoptosis. To elucidate the possible mechanisms of this resistance, we examined the mRNA transcripts of genes related to Fas in 10 hepatitis B virus (HBV)-associated HCC cell lines and six HBV-associated HCC tissues. Most of the HBV-associated HCC cell lines showed markedly decreased Fas expression. Some cell lines expressed FAP, a possible inhibitor of apoptosis, or showed downregulated expression of FADD or FLICE, molecules essential to Fas-mediated apoptosis. All six HBV-associated HCC tissues also showed decreased Fas expression compared with their non-malignant counterparts. Our data demonstrate that HBV-associated HCC showed a common defect in the expression of Fas, upregulation of FAP and downregulation of downstream molecules such as FADD and FLICE. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Ireland | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Apoptosis/genetics* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/virology | - |
dc.subject.MESH | Down-Regulation | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Fluorescent Antibody Technique | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Hepatitis B/complications | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Liver Neoplasms/virology | - |
dc.subject.MESH | Proto-Oncogene Proteins/genetics* | - |
dc.subject.MESH | RNA, Messenger/analysis | - |
dc.subject.MESH | RNA, Neoplasm/analysis | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.subject.MESH | Up-Regulation | - |
dc.title | Expression of Fas-related genes in human hepatocellular carcinomas | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Jeong-Jhin Kim | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.identifier.doi | 10.1016/s0304-3835(98)00251-1 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A02144 | - |
dc.relation.journalcode | J00448 | - |
dc.identifier.eissn | 1872-7980 | - |
dc.identifier.pmid | 10025875 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0304383598002511 | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | 김세종 | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.contributor.affiliatedAuthor | 신전수 | - |
dc.citation.volume | 134 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 162 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, Vol.134(2) : 155-162, 1998 | - |
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