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Effect of a calcium sulfate implant with calcium sulfate barrier on periodontal healing in 3-wall intrabony defects in dogs

Authors
 Chong-Kwan Kim  ;  Hyun-Young Kim  ;  Jung-Kiu Chai  ;  Kyoo-Sung Cho  ;  Ik-Sang Moon  ;  Seong-Ho Choi  ;  John S. Sottosanti  ;  Ulf M.E. Wikesjö 
Citation
 JOURNAL OF PERIODONTOLOGY, Vol.69(9) : 982-988, 1998 
Journal Title
 JOURNAL OF PERIODONTOLOGY 
ISSN
 0022-3492 
Issue Date
1998
MeSH
Alveolar Bone Loss/physiopathology ; Alveolar Bone Loss/surgery* ; Alveolar Process/pathology ; Alveolar Process/physiopathology ; Animals ; Bicuspid ; Bone Matrix/transplantation ; Bone Regeneration ; Bone Substitutes/chemistry ; Bone Substitutes/therapeutic use* ; Calcium Sulfate/chemistry ; Calcium Sulfate/therapeutic use* ; Connective Tissue/pathology ; Decalcification Technique ; Dental Cementum/pathology ; Dental Cementum/physiopathology ; Dogs ; Evaluation Studies as Topic ; Freeze Drying ; Gingivoplasty ; Mandible/surgery ; Maxilla/surgery ; Membranes, Artificial* ; Periodontium/pathology ; Periodontium/physiopathology* ; Regeneration ; Surface Properties ; Surgical Flaps ; Tooth Root/pathology ; Transplantation, Homologous ; Treatment Outcome ; Wound Healing
Abstract
This controlled, split-mouth, preclinical study was designed to evaluate outcome following surgical implantation of an allogeneic, freeze-dried demineralized bone matrix-calcium sulfate (DBM+CS) composite with a CS barrier in 3-wall intrabony periodontal defects in 4 dogs. Control conditions included surgical implantation of DBM or CS and gingival flap surgery (GFS) alone. Three-wall intrabony defects (4x4x4 mm) were surgically created at the mesial and distal aspect of the maxillary and mandibular first and third premolars, respectively. Maxillary and mandibular defects each received 1 of the 4 experimental conditions. Experimental conditions were rotated between defect sites in subsequent animals. Block sections of the defects were collected at sacrifice 8 weeks postsurgery and processed for histometric analysis. Histometric defect height (means +/- SD) for the DBM+CS, DBM, CS, and GFS groups amounted to 4.2 +/- 0.5, 4.3 +/- 0.7, 4.0 +/- 0.2, and 4.1 +/- 0.2 mm, respectively. Connective tissue adhesion (connective tissue contact to the root without apparent cementum formation) amounted to 0.4 +/- 0.3, 0.4 +/- 0.3, 0.5 +/- 0.2, and 1.6 +/- 0.5 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Cementum regeneration amounted to 3.0 +/- 0.3, 3.1 +/- 0.4, 2.5 +/- 0.4, and 1.6 +/- 0.3 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being significantly different from the GFS group (P < 0.05). Alveolar bone regeneration amounted to 2.7 +/- 0.4, 2.7 +/- 0.3, 1.8 +/- 0.5, and 0.7 +/- 0.1 mm for the DBM+CS, DBM, CS, and GFS groups, respectively; the DBM+CS, DBM, and CS groups being different from the GFS group (P < 0.05), and the DBM+CS and DBM groups being different from the CS group (P < 0.05). None of the DBM-containing implants provided evidence of bone metabolic activity. In summary, surgical implantation of DBM and CS, alone or in combination, may result in significantly improved regeneration of alveolar bone and cementum in this preclinical model. Observed regeneration is likely unrelated to a biologic activity inherent in DBM. Rather it appears that space-providing properties of the implants supported observed regeneration.
Full Text
http://www.joponline.org/doi/abs/10.1902/jop.1998.69.9.982
DOI
10.1902/jop.1998.69.9.982
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Moon, Ik Sang(문익상)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Chai, Jung Kyu(채중규)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176390
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