68 95

Cited 0 times in

3'-Sialyllactose Prebiotics Prevents Skin Inflammation via Regulatory T Cell Differentiation in Atopic Dermatitis Mouse Models

 Li-Jung Kang  ;  Eunjeong Oh  ;  Chanmi Cho  ;  HoKeun Kwon  ;  Choong-Gu Lee  ;  Jimin Jeon  ;  Hyemi Lee  ;  Sangil Choi  ;  Seong Jae Han  ;  Jiho Nam  ;  Chi-Une Song  ;  Hyunho Jung  ;  Hye Young Kim  ;  Eun-Jung Park  ;  Eun-Ju Choi  ;  Jooyoung Kim  ;  Seong-Il Eyun  ;  Siyoung Yang 
 SCIENTIFIC REPORTS, Vol.10(1) : 5603, 2020-03 
Journal Title
Issue Date
3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the effect of 3'-SL on Treg responses in atopic dermatitis (AD) pathogenesis. Oral administration of 3'-SL reduced AD-like symptoms such as ear, epidermal, and dermal thickness in repeated topical application of house dust mites (HDM) and 2,4-dinitrochlorobenzene (DNCB). 3'-SL inhibited IgE, IL-1β, IL-6, and TNF-α secretion and markedly downregulated AD-related cytokines including IL-4, IL-5, IL-6, IL-13, IL-17, IFN-γ, TNF-α, and Tslp through regulation of NF-κB in ear tissue. Additionally, in vitro assessment of Treg differentiation revealed that 3'-SL directly induced TGF-β-mediated Treg differentiation. Furthermore, 3'-SL administration also ameliorated sensitization and elicitation of AD pathogenesis by suppressing mast cell infiltration and production of IgE and pro-inflammatory cytokines in mouse serum by mediating the Treg response. Furthermore, Bifidobacterium population was also increased by 3'-SL administration as prebiotics. Our data collectively show that 3'-SL has therapeutic effects against AD progression by inducing Treg differentiation, downregulating AD-related cytokines, and increasing the Bifidobacterium population.
Files in This Item:
T202001711.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Ho-Keun(권호근) ORCID logo https://orcid.org/0000-0003-3175-0376
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.