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3'-Sialyllactose Prebiotics Prevents Skin Inflammation via Regulatory T Cell Differentiation in Atopic Dermatitis Mouse Models

DC FieldValueLanguage
dc.contributor.author권호근-
dc.date.accessioned2020-06-17T01:05:45Z-
dc.date.available2020-06-17T01:05:45Z-
dc.date.issued2020-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176247-
dc.description.abstract3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the effect of 3'-SL on Treg responses in atopic dermatitis (AD) pathogenesis. Oral administration of 3'-SL reduced AD-like symptoms such as ear, epidermal, and dermal thickness in repeated topical application of house dust mites (HDM) and 2,4-dinitrochlorobenzene (DNCB). 3'-SL inhibited IgE, IL-1β, IL-6, and TNF-α secretion and markedly downregulated AD-related cytokines including IL-4, IL-5, IL-6, IL-13, IL-17, IFN-γ, TNF-α, and Tslp through regulation of NF-κB in ear tissue. Additionally, in vitro assessment of Treg differentiation revealed that 3'-SL directly induced TGF-β-mediated Treg differentiation. Furthermore, 3'-SL administration also ameliorated sensitization and elicitation of AD pathogenesis by suppressing mast cell infiltration and production of IgE and pro-inflammatory cytokines in mouse serum by mediating the Treg response. Furthermore, Bifidobacterium population was also increased by 3'-SL administration as prebiotics. Our data collectively show that 3'-SL has therapeutic effects against AD progression by inducing Treg differentiation, downregulating AD-related cytokines, and increasing the Bifidobacterium population.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title3'-Sialyllactose Prebiotics Prevents Skin Inflammation via Regulatory T Cell Differentiation in Atopic Dermatitis Mouse Models-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorLi-Jung Kang-
dc.contributor.googleauthorEunjeong Oh-
dc.contributor.googleauthorChanmi Cho-
dc.contributor.googleauthorHoKeun Kwon-
dc.contributor.googleauthorChoong-Gu Lee-
dc.contributor.googleauthorJimin Jeon-
dc.contributor.googleauthorHyemi Lee-
dc.contributor.googleauthorSangil Choi-
dc.contributor.googleauthorSeong Jae Han-
dc.contributor.googleauthorJiho Nam-
dc.contributor.googleauthorChi-Une Song-
dc.contributor.googleauthorHyunho Jung-
dc.contributor.googleauthorHye Young Kim-
dc.contributor.googleauthorEun-Jung Park-
dc.contributor.googleauthorEun-Ju Choi-
dc.contributor.googleauthorJooyoung Kim-
dc.contributor.googleauthorSeong-Il Eyun-
dc.contributor.googleauthorSiyoung Yang-
dc.identifier.doi10.1038/s41598-020-62527-5-
dc.contributor.localIdA05782-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32221370-
dc.contributor.alternativeNameKwon, Ho-Keun-
dc.contributor.affiliatedAuthor권호근-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage5603-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 5603, 2020-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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