Cited 28 times in
3'-Sialyllactose Prebiotics Prevents Skin Inflammation via Regulatory T Cell Differentiation in Atopic Dermatitis Mouse Models
DC Field | Value | Language |
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dc.contributor.author | 권호근 | - |
dc.date.accessioned | 2020-06-17T01:05:45Z | - |
dc.date.available | 2020-06-17T01:05:45Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176247 | - |
dc.description.abstract | 3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the effect of 3'-SL on Treg responses in atopic dermatitis (AD) pathogenesis. Oral administration of 3'-SL reduced AD-like symptoms such as ear, epidermal, and dermal thickness in repeated topical application of house dust mites (HDM) and 2,4-dinitrochlorobenzene (DNCB). 3'-SL inhibited IgE, IL-1β, IL-6, and TNF-α secretion and markedly downregulated AD-related cytokines including IL-4, IL-5, IL-6, IL-13, IL-17, IFN-γ, TNF-α, and Tslp through regulation of NF-κB in ear tissue. Additionally, in vitro assessment of Treg differentiation revealed that 3'-SL directly induced TGF-β-mediated Treg differentiation. Furthermore, 3'-SL administration also ameliorated sensitization and elicitation of AD pathogenesis by suppressing mast cell infiltration and production of IgE and pro-inflammatory cytokines in mouse serum by mediating the Treg response. Furthermore, Bifidobacterium population was also increased by 3'-SL administration as prebiotics. Our data collectively show that 3'-SL has therapeutic effects against AD progression by inducing Treg differentiation, downregulating AD-related cytokines, and increasing the Bifidobacterium population. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 3'-Sialyllactose Prebiotics Prevents Skin Inflammation via Regulatory T Cell Differentiation in Atopic Dermatitis Mouse Models | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Li-Jung Kang | - |
dc.contributor.googleauthor | Eunjeong Oh | - |
dc.contributor.googleauthor | Chanmi Cho | - |
dc.contributor.googleauthor | HoKeun Kwon | - |
dc.contributor.googleauthor | Choong-Gu Lee | - |
dc.contributor.googleauthor | Jimin Jeon | - |
dc.contributor.googleauthor | Hyemi Lee | - |
dc.contributor.googleauthor | Sangil Choi | - |
dc.contributor.googleauthor | Seong Jae Han | - |
dc.contributor.googleauthor | Jiho Nam | - |
dc.contributor.googleauthor | Chi-Une Song | - |
dc.contributor.googleauthor | Hyunho Jung | - |
dc.contributor.googleauthor | Hye Young Kim | - |
dc.contributor.googleauthor | Eun-Jung Park | - |
dc.contributor.googleauthor | Eun-Ju Choi | - |
dc.contributor.googleauthor | Jooyoung Kim | - |
dc.contributor.googleauthor | Seong-Il Eyun | - |
dc.contributor.googleauthor | Siyoung Yang | - |
dc.identifier.doi | 10.1038/s41598-020-62527-5 | - |
dc.contributor.localId | A05782 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 32221370 | - |
dc.contributor.alternativeName | Kwon, Ho-Keun | - |
dc.contributor.affiliatedAuthor | 권호근 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 5603 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.10(1) : 5603, 2020-03 | - |
dc.identifier.rimsid | 67542 | - |
dc.type.rims | ART | - |
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