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Neural Substrates for Poststroke Complex Regional Pain Syndrome Type I: A Retrospective Case-Control Study Using Voxel-Based Lesion Symptom Mapping Analysis

Authors
 Jun Yup Kim  ;  Seo Yeon Yoon  ;  Jinna Kim  ;  Yong Hyu Jeong  ;  Yong Wook Kim 
Citation
 PAIN, Vol.161(6) : 1311-1320, 2020-06 
Journal Title
 PAIN 
ISSN
 0304-3959 
Issue Date
2020-06
Abstract
Poststroke complex regional pain syndrome (CRPS) is characterized by swelling, pain, and changes in the skin that appear on the affected wrist and hand. In this retrospective study, we analyzed the relationship between poststroke CRPS and the location of stroke lesion. From all patients admitted to our hospital from 2009 to 2019, we recruited 80 patients affected by their first unilateral stroke who met the inclusion/exclusion criteria. Thirty-eight patients diagnosed with CRPS after stroke were assigned to the experimental group according to the "Budapest criteria" adopted by the International Association for the Study of Pain, and 42 patients without CRPS were included as controls. Regions of interest were manually drawn on T1-weighted magnetic resonance images, and data were normalized to a standard brain template. In the poststroke CRPS group, the relationship between the location of brain lesion and pain severity was analyzed using Freedman-Lane multivariable regression adjusting for Medication Quantification Scale rating, which was the only parameter to show a statistically significant correlation with pain intensity. A threshold of P < 0.01 was considered statistically significant for all voxel-based lesion symptom mapping tests, corrected for multiple comparisons with 5000 permutations. Analyses using voxel-wise subtraction and Liebermeister statistics indicated that the corticospinal tract (CST) was associated with the development of poststroke CRPS. Statistically significant correlations were found between pain intensity and the CST and the adjacent lentiform nucleus. Our results suggest that the CST may be a relevant neural structure for development of poststroke CRPS and the intensity of pain caused by the syndrome.
Full Text
https://journals.lww.com/pain/FullText/2020/06000/Neural_substrates_for_poststroke_complex_regional.19.aspx
DOI
10.1097/j.pain.0000000000001816
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yong Wook(김용욱) ORCID logo https://orcid.org/0000-0002-5234-2454
Kim, Jun Yup(김준엽)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Jeong, Yong Hyu(정용휴) ORCID logo https://orcid.org/0000-0002-0198-0026
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176240
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