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Reduced Activation of the Ventromedial Prefrontal Cortex During Self-Referential Processing in Individuals at Ultra-High Risk for Psychosis

Authors
 Hye Yoon Park  ;  Kyoungri Park  ;  Eunchong Seo  ;  Se Jun Koo  ;  Minji Bang  ;  Jin Young Park  ;  Jee In Kang  ;  Eun Lee  ;  Seung-Koo Lee  ;  Suk Kyoon An 
Citation
 AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, Vol.54(5) : 528-538, 2020-05 
Journal Title
 AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY 
ISSN
 0004-8674 
Issue Date
2020-05
Keywords
Self-referential processing ; basic self-disorder ; episodic memory ; third-person perspective ; ultra-high risk for psychosis ; working memory
Abstract
Objective: Defects in self-referential processing and perspective-taking are core characteristics that may underlie psychotic symptoms and impaired social cognition in schizophrenia. Here, we investigated the neural correlates of self-referential processing regardless of the perspective taken and third-person perspective-taking regardless of the target person to judge relevance in individuals at ultra-high risk for psychosis. We also explored relationships between alterations in neural activity and neurocognitive function and basic self ('ipseity') disorder. Methods: Twenty-two ultra-high-risk individuals and 28 healthy controls completed a functional magnetic resonance imaging task. While being scanned, participants were asked to take a first-person perspective or to put themselves in their close relative's place thereby adopting a third-person perspective during judgments of the relevance of personality trait adjectives to one's self and a close relative. Results: For self-referential (vs other-referential) processing, ultra-high-risk individuals showed less neural activity in the left ventromedial prefrontal cortex/medial orbitofrontal cortex, which was correlated with poor working memory performance. When taking a third-person perspective (vs first-person perspective), ultra-high-risk individuals showed more activity in the middle occipital gyrus. Conclusion: Taken together, our findings suggest that ultra-high-risk individuals already show aberrant neural activity during self-referential processing which may possibly be related to engagement of working memory resources.
Full Text
https://journals.sagepub.com/doi/full/10.1177/0004867419898529
DOI
10.1177/0004867419898529
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Park, Hye Yoon(박혜윤) ORCID logo https://orcid.org/0000-0001-9579-8112
Seo, Eunchong(서은총) ORCID logo https://orcid.org/0000-0003-2644-266X
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176210
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