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Motor Cortex Hypointensity on Susceptibility-Weighted Imaging: A Potential Imaging Marker of Iron Accumulation in Patients With Cognitive Impairment

Authors
 Mina Park  ;  Yeonsil Moon  ;  Seol-Heui Han  ;  Won-Jin Moon 
Citation
 NEURORADIOLOGY, Vol.61(6) : 675-683, 2019-06 
Journal Title
 NEURORADIOLOGY 
ISSN
 0028-3940 
Issue Date
2019-06
Keywords
Alzheimer’s disease ; Cognitive dysfunction ; Dementia ; Iron ; Magnetic resonance imaging ; Susceptibility-weighted imaging
Abstract
Purpose: To assess the prevalence and characteristics of motor cortex hypointensity on 3-T susceptibility-weighted imaging (SWI) in patients with cognitive impairment and examine its clinical significance. Methods: The institutional review board approved this retrospective study and waived the requirement for informed consent. A total of 127 patients with a clinical diagnosis of probable Alzheimer's disease (AD) (n = 32) or mild cognitive impairment (MCI) (n = 95) and 127 age- and sex-matched control subjects underwent 3-T brain magnetic resonance imaging. SWI was analyzed for both subjective visual scoring and the quantitative estimation of phase shift in the posterior bank of the motor cortex. A multivariate logistic regression analysis was performed to identify clinical and imaging variables associated with motor cortex hypointensity on SWI. Results: Motor cortex hypointensity on SWI was observed in 94/127 cognitively impaired patients (74.0%) and 72/127 control subjects (56.7%) (p = 0.004). Age was the only variable that was significantly associated with motor cortex hypointensity in patients with cognitive impairment (odds ratio, 1.15; 95% confidence interval, 1.065-1.242; p < 0.001). The quantitative analysis confirmed a significant increase in phase shifting in the posterior bank of the motor cortex in patients with positive motor cortex hypointensity on SWI (p < 0.001). Conclusion: Motor cortex hypointensity on SWI was more frequently found in patients with cognitive impairment than in age-matched controls and was positively associated with age. Thus, it may be a potential imaging marker of iron accumulation in patients with MCI or AD.
Full Text
https://link.springer.com/article/10.1007%2Fs00234-019-02159-3
DOI
10.1007/s00234-019-02159-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Mina(박미나) ORCID logo https://orcid.org/0000-0002-2005-7560
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175876
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