Cited 11 times in
Motor Cortex Hypointensity on Susceptibility-Weighted Imaging: A Potential Imaging Marker of Iron Accumulation in Patients With Cognitive Impairment
DC Field | Value | Language |
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dc.contributor.author | 박미나 | - |
dc.date.accessioned | 2020-06-04T08:46:06Z | - |
dc.date.available | 2020-06-04T08:46:06Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 0028-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175876 | - |
dc.description.abstract | Purpose: To assess the prevalence and characteristics of motor cortex hypointensity on 3-T susceptibility-weighted imaging (SWI) in patients with cognitive impairment and examine its clinical significance. Methods: The institutional review board approved this retrospective study and waived the requirement for informed consent. A total of 127 patients with a clinical diagnosis of probable Alzheimer's disease (AD) (n = 32) or mild cognitive impairment (MCI) (n = 95) and 127 age- and sex-matched control subjects underwent 3-T brain magnetic resonance imaging. SWI was analyzed for both subjective visual scoring and the quantitative estimation of phase shift in the posterior bank of the motor cortex. A multivariate logistic regression analysis was performed to identify clinical and imaging variables associated with motor cortex hypointensity on SWI. Results: Motor cortex hypointensity on SWI was observed in 94/127 cognitively impaired patients (74.0%) and 72/127 control subjects (56.7%) (p = 0.004). Age was the only variable that was significantly associated with motor cortex hypointensity in patients with cognitive impairment (odds ratio, 1.15; 95% confidence interval, 1.065-1.242; p < 0.001). The quantitative analysis confirmed a significant increase in phase shifting in the posterior bank of the motor cortex in patients with positive motor cortex hypointensity on SWI (p < 0.001). Conclusion: Motor cortex hypointensity on SWI was more frequently found in patients with cognitive impairment than in age-matched controls and was positively associated with age. Thus, it may be a potential imaging marker of iron accumulation in patients with MCI or AD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | NEURORADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Motor Cortex Hypointensity on Susceptibility-Weighted Imaging: A Potential Imaging Marker of Iron Accumulation in Patients With Cognitive Impairment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Mina Park | - |
dc.contributor.googleauthor | Yeonsil Moon | - |
dc.contributor.googleauthor | Seol-Heui Han | - |
dc.contributor.googleauthor | Won-Jin Moon | - |
dc.identifier.doi | 10.1007/s00234-019-02159-3 | - |
dc.contributor.localId | A01460 | - |
dc.relation.journalcode | J02358 | - |
dc.identifier.eissn | 1432-1920 | - |
dc.identifier.pmid | 30693411 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00234-019-02159-3 | - |
dc.subject.keyword | Alzheimer’s disease | - |
dc.subject.keyword | Cognitive dysfunction | - |
dc.subject.keyword | Dementia | - |
dc.subject.keyword | Iron | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Susceptibility-weighted imaging | - |
dc.contributor.alternativeName | Park, Mina | - |
dc.contributor.affiliatedAuthor | 박미나 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 675 | - |
dc.citation.endPage | 683 | - |
dc.identifier.bibliographicCitation | NEURORADIOLOGY, Vol.61(6) : 675-683, 2019-06 | - |
dc.identifier.rimsid | 64406 | - |
dc.type.rims | ART | - |
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