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Motor Cortex Hypointensity on Susceptibility-Weighted Imaging: A Potential Imaging Marker of Iron Accumulation in Patients With Cognitive Impairment

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dc.contributor.author박미나-
dc.date.accessioned2020-06-04T08:46:06Z-
dc.date.available2020-06-04T08:46:06Z-
dc.date.issued2019-06-
dc.identifier.issn0028-3940-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175876-
dc.description.abstractPurpose: To assess the prevalence and characteristics of motor cortex hypointensity on 3-T susceptibility-weighted imaging (SWI) in patients with cognitive impairment and examine its clinical significance. Methods: The institutional review board approved this retrospective study and waived the requirement for informed consent. A total of 127 patients with a clinical diagnosis of probable Alzheimer's disease (AD) (n = 32) or mild cognitive impairment (MCI) (n = 95) and 127 age- and sex-matched control subjects underwent 3-T brain magnetic resonance imaging. SWI was analyzed for both subjective visual scoring and the quantitative estimation of phase shift in the posterior bank of the motor cortex. A multivariate logistic regression analysis was performed to identify clinical and imaging variables associated with motor cortex hypointensity on SWI. Results: Motor cortex hypointensity on SWI was observed in 94/127 cognitively impaired patients (74.0%) and 72/127 control subjects (56.7%) (p = 0.004). Age was the only variable that was significantly associated with motor cortex hypointensity in patients with cognitive impairment (odds ratio, 1.15; 95% confidence interval, 1.065-1.242; p < 0.001). The quantitative analysis confirmed a significant increase in phase shifting in the posterior bank of the motor cortex in patients with positive motor cortex hypointensity on SWI (p < 0.001). Conclusion: Motor cortex hypointensity on SWI was more frequently found in patients with cognitive impairment than in age-matched controls and was positively associated with age. Thus, it may be a potential imaging marker of iron accumulation in patients with MCI or AD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfNEURORADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMotor Cortex Hypointensity on Susceptibility-Weighted Imaging: A Potential Imaging Marker of Iron Accumulation in Patients With Cognitive Impairment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorMina Park-
dc.contributor.googleauthorYeonsil Moon-
dc.contributor.googleauthorSeol-Heui Han-
dc.contributor.googleauthorWon-Jin Moon-
dc.identifier.doi10.1007/s00234-019-02159-3-
dc.contributor.localIdA01460-
dc.relation.journalcodeJ02358-
dc.identifier.eissn1432-1920-
dc.identifier.pmid30693411-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00234-019-02159-3-
dc.subject.keywordAlzheimer’s disease-
dc.subject.keywordCognitive dysfunction-
dc.subject.keywordDementia-
dc.subject.keywordIron-
dc.subject.keywordMagnetic resonance imaging-
dc.subject.keywordSusceptibility-weighted imaging-
dc.contributor.alternativeNamePark, Mina-
dc.contributor.affiliatedAuthor박미나-
dc.citation.volume61-
dc.citation.number6-
dc.citation.startPage675-
dc.citation.endPage683-
dc.identifier.bibliographicCitationNEURORADIOLOGY, Vol.61(6) : 675-683, 2019-06-
dc.identifier.rimsid64406-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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