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Frontal Atrophy as a Marker for Dementia Conversion in Parkinson's Disease With Mild Cognitive Impairment

 Seok Jong Chung  ;  Han Soo Yoo  ;  Yang Hyun Lee  ;  Hye Sun Lee  ;  Byoung Seok Ye  ;  Young H Sohn  ;  Hunki Kwon  ;  Phil Hyu Lee 
 HUMAN BRAIN MAPPING, Vol.40(13) : 3784-3794, 2019-09 
Journal Title
Issue Date
Aged ; Atrophy / pathology ; Cerebral Cortex / diagnostic imaging ; Cerebral Cortex / pathology* ; Cognitive Dysfunction / diagnostic imaging ; Cognitive Dysfunction / pathology* ; Cognitive Dysfunction / physiopathology ; Dementia / diagnostic imaging ; Dementia / pathology* ; Dementia / physiopathology ; Disease Progression* ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Parkinson Disease / diagnostic imaging ; Parkinson Disease / pathology* ; Parkinson Disease / physiopathology ; Prefrontal Cortex / diagnostic imaging ; Prefrontal Cortex / pathology ; Retrospective Studies
Parkinson's disease dementia ; converter ; frontostriatal ; mild cognitive impairment (MCI) ; posterior cortical
This study aimed to investigate the cortical neural correlates of dementia conversion in Parkinson's disease with mild cognitive impairment (PD-MCI). We classified 112 patients with drug-naïve early stage PD meeting criteria for PD-MCI into either PD with dementia (PDD) converters (n = 34) or nonconverters (n = 78), depending on whether they developed dementia within 4 years of PD diagnosis. Cortical thickness analyses were performed in 34 PDD converters and 34 matched nonconverters. Additionally, a linear discriminant analysis was performed to distinguish PDD converters from nonconverters using cortical thickness of the regions that differed between the two groups. The PDD converters had higher frequencies of multiple domain MCI and amnestic MCI with storage failure, and poorer cognitive performances on frontal/executive, memory, and language function domains than did the nonconverters. Cortical thinning extending from the posterior cortical area into the frontal region was observed in PDD converters relative to nonconverters. The discriminant analysis showed that the prediction model with two cortical thickness variables in the right medial superior frontal and left olfactory cortices optimally distinguished PDD converters from nonconverters. Our data suggest that cortical thinning in the frontal areas including the olfactory cortex is a marker for early dementia conversion in PD-MCI.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
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