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Association between serum carbohydrate antigen 19-9 levels and leukoaraiosis in middle-aged and older adults: A cross-sectional study

 Da-Hye Son  ;  Hye Sun Lee  ;  Yong-Jae Lee 
 ATHEROSCLEROSIS, Vol.292 : 188-192, 2020 
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Carbohydrate antigen 19–9 ; Leukoaraiosis ; White matter disease
BACKGROUND AND AIMS: Leukoaraiosis refers to lesions with high signal intensity on magnetic resonance imaging (MRI) in periventricular and subcortical white matter that results from chronic microvascular ischemic brain damage. Increasing evidence suggests that serum CA 19-9 is associated with non-malignant conditions including type 2 diabetes, dyslipidemia, and metabolic syndrome, which are closely related to microangiopathy. Thus, we hypothesized that serum CA 19-9 levels would be associated with cerebrovascular microangiopathy measured by leukoaraiosis among middle-aged and older adults. METHODS: This cross-sectional study included 1833 Korean adults aged ≥45 years who participated in a health examination program between 2010 and 2011. Serum CA 19-9 levels were quantified by chemiluminescence immunoassay and categorized as quartiles: Q1: ≤4.5, Q2: 4.6-7.5, Q2: 7.6-12.2, and Q4: ≥12.3 ng/mL. Odds ratios (ORs) and 95% confidence intervals (CIs) for leukoaraiosis based on brain MRI scans were calculated across serum CA19-9 quartiles using multiple logistic regression analysis. RESULTS: The overall prevalence of leukoaraiosis was 4.6% and increased with serum CA 19-9 quartiles. Compared to the lowest quartile, the OR (95% CI) of the highest CA 19-9 quartile for leukoaraiosis was 2.20 (1.10-4.42) after adjusting for age, sex, BMI, regular exercise, hypertension, type 2 diabetes, dyslipidemia, smoking status, and alcohol drinking. CONCLUSIONS: Serum CA 19-9 levels were positively and independently associated with leukoaraiosis. Our findings indicate that serum CA 19-9 level might be a useful additional measure for assessing cerebrovascular microangiopathy in clinical settings.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Son, Da‐Hye(손다혜) ORCID logo https://orcid.org/0000-0001-7464-996X
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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