Total body irradiation ; Tomotherapy ; TomoHelical ; TomoDirect ; Field junction ; Dose gradient ; Setup error
Abstract
Background: Tomotherapy-based total body irradiation (TBI) is performed using the head-first position (HFP) and
feet-first position (FFP) due to treatment length exceeding the 135 cm limit. To reduce the dosimetric variation at
the match lines, we propose and verify a volumetric gradient matching technique (VGMT) by combining
TomoHelical (TH) and TomoDirect (TD) modes.
Methods: Two planning CT image sets were acquired with HFP and FFP using 15 × 55 × 18 cm3 of solid water
phantom. Planning target volume (PTV) was divided into upper, lower, and gradient volumes. The junction
comprised 2-cm thick five and seven gradient volumes (5-GVs and 7-GVs) to create a dose distribution with a
gentle slope. TH-IMRT and TD-IMRT plans were generated with 5-GVs and 7-GVs. The setup error in the calculated
dose was assessed by shifting dose distribution of the FFP plan by 5, 10, 15, and 20 mm in the longitudinal
direction and comparing it with the original. Doses for 95% (D95) and 5% of the PTV (D5) were calculated for all
simulated setup error plans. Absolute dose measurements were performed using an ionization chamber in the
junction.
Results: The TH&TD plan produced a linear gradient in junction volume, comparable to that of the TH&TH plan. D5
of the PTV was 110% of the prescribed dose when the FFP plan was shifted 0.7 cm and 1.2 cm in the superior
direction for 5-GVs and 7-GVs. D95 of the PTV decreased to < 90% of the prescribed dose when the FF plan was
shifted 1.1 cm and 1.3 cm in the inferior direction for 5-GVs and 7-GVs. The absolute measured dose showed a
good correlation with the calculated dose in the gradient junction volume. The average percent difference (±SD) in
all measured points was − 0.7 ± 1.6%, and the average dose variations between depths was − 0.18 ± 1.07%.
Conclusion: VGMT can create a linear dose gradient across the junction area in both TH&TH and TH&TD and can
minimize the dose sensitivity to longitudinal setup errors in tomotherapy-based TBI.