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Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation

Authors
 Chul Hoon Kim  ;  Joo Hee Kim  ;  Chung Y. Hsu  ;  Y S Ahn 
Citation
 FEBS Letters, Vol.449(1) : 28-32, 1999 
Journal Title
 FEBS Letters 
ISSN
 0014-5793 
Issue Date
1999
MeSH
Animals ; Antioxidants/metabolism* ; Antioxidants/pharmacology ; Cations ; Cattle ; Cells, Cultured ; Metals ; NF-kappa B/antagonists & inhibitors* ; Pyrrolidines/metabolism* ; Pyrrolidines/pharmacology ; Thiocarbamates/metabolism* ; Thiocarbamates/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology ; Zinc/metabolism*
Abstract
Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation. PDTC inhibited basal NF-kappaB activity of endothelial cells. PDTC, however, failed to inhibit basal NF-kappaB activity after withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of zinc. When various preparations of metal ion-EDTA were tested with PDTC in serum-containing media, only Zn-EDTA failed to block the inhibitory effect of PDTC. The dependence on zinc was also noted in PDTC inhibition of NF-kappaB stimulated by TNF alpha. These facts suggest that zinc is required for PDTC inhibition of NF-kappaB activation.
Files in This Item:
T199903326.pdf Download
DOI
10.1016/s0014-5793(99)00390-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Ahn, Young Soo(안영수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174319
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