Cited 78 times in
Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철훈 | - |
dc.contributor.author | 안영수 | - |
dc.date.accessioned | 2020-01-23T05:28:52Z | - |
dc.date.available | 2020-01-23T05:28:52Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174319 | - |
dc.description.abstract | Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-kappaB) activation. PDTC inhibited basal NF-kappaB activity of endothelial cells. PDTC, however, failed to inhibit basal NF-kappaB activity after withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of zinc. When various preparations of metal ion-EDTA were tested with PDTC in serum-containing media, only Zn-EDTA failed to block the inhibitory effect of PDTC. The dependence on zinc was also noted in PDTC inhibition of NF-kappaB stimulated by TNF alpha. These facts suggest that zinc is required for PDTC inhibition of NF-kappaB activation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.relation.isPartOf | FEBS Letters | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antioxidants/metabolism* | - |
dc.subject.MESH | Antioxidants/pharmacology | - |
dc.subject.MESH | Cations | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Metals | - |
dc.subject.MESH | NF-kappa B/antagonists & inhibitors* | - |
dc.subject.MESH | Pyrrolidines/metabolism* | - |
dc.subject.MESH | Pyrrolidines/pharmacology | - |
dc.subject.MESH | Thiocarbamates/metabolism* | - |
dc.subject.MESH | Thiocarbamates/pharmacology | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/pharmacology | - |
dc.subject.MESH | Zinc/metabolism* | - |
dc.title | Zinc is required in pyrrolidine dithiocarbamate inhibition of NF-kappaB activation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Joo Hee Kim | - |
dc.contributor.googleauthor | Chung Y. Hsu | - |
dc.contributor.googleauthor | Y S Ahn | - |
dc.identifier.doi | 10.1016/s0014-5793(99)00390-7 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A02246 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 10225421 | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | 김철훈 | - |
dc.contributor.affiliatedAuthor | 안영수 | - |
dc.citation.volume | 449 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 28 | - |
dc.citation.endPage | 32 | - |
dc.identifier.bibliographicCitation | FEBS Letters, Vol.449(1) : 28-32, 1999 | - |
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