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소아 재생불량성빈혈에서 HLA-DR 대립유전자의 발현이 면역억제치료 반응에 미치는 영향

Other Titles
 Response to Immunosuppressive Therapy rind an HIA-DR Allele in Children with Aplastic Anemia 
 김길영  ;  조현상  ;  신전수  ;  유철주  ;  양창현  ;  박송희  ;  박세명  ;  김문규  ;  김황민  ;  김세종 
 Korean Journal of Hematology (대한혈액학회지), Vol.34(1) : 36-42, 1999 
Journal Title
 Korean Journal of Hematology (대한혈액학회지) 
Issue Date
Aplastic anemia ; HLA-DR ; Immunosuppresive therapy
Background: Genetic susceptibility to a variety of disease has bssn shown and it has recently been suggested that aplastic anemia is more common in adults who are HIA- DR2+than in the general population. Methods: To investigate whether certain HLA-DR gene is more common in children with aplastic anemia and HLA-DR2+ gene is associated with susceptibility to cyclosporine A(CyA), we analyzed the results of HLA-DR typing in 37 children with aplastic anemia with sequence specific oligonucleotide probe(SSOP) method. Results: Eight patients were DR2+, and there was no more common than the normal population. All of the 8 patients wlth DR2+ were DRB1*1501+ with high resolution HLA typing. Of the 8 patients with DRB1*1501+, 3 patients were treated with CyA alone(2 patients) or CyA plus ATG(1 patient), 2 patients were treated with ATG(1 patient) or ALG alone(1 patient). Patients treatsd with CyA only or CyA plus ATG had either a complete(1 patient) or partial(2 patients) response and patients treated ATG or ALG alone had no response. Conclusion: Although incidence of HLA-DR2 was not significantly higher in children with aplastic anemia then normal population, response rate to CyA was significantly high in the DR2+ patients.
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1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
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