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소아 재생불량성빈혈에서 HLA-DR 대립유전자의 발현이 면역억제치료 반응에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 신전수 | - |
dc.date.accessioned | 2020-01-23T05:24:19Z | - |
dc.date.available | 2020-01-23T05:24:19Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1225-0546 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174251 | - |
dc.description.abstract | Background: Genetic susceptibility to a variety of disease has bssn shown and it has recently been suggested that aplastic anemia is more common in adults who are HIA- DR2+than in the general population. Methods: To investigate whether certain HLA-DR gene is more common in children with aplastic anemia and HLA-DR2+ gene is associated with susceptibility to cyclosporine A(CyA), we analyzed the results of HLA-DR typing in 37 children with aplastic anemia with sequence specific oligonucleotide probe(SSOP) method. Results: Eight patients were DR2+, and there was no more common than the normal population. All of the 8 patients wlth DR2+ were DRB1*1501+ with high resolution HLA typing. Of the 8 patients with DRB1*1501+, 3 patients were treated with CyA alone(2 patients) or CyA plus ATG(1 patient), 2 patients were treated with ATG(1 patient) or ALG alone(1 patient). Patients treatsd with CyA only or CyA plus ATG had either a complete(1 patient) or partial(2 patients) response and patients treated ATG or ALG alone had no response. Conclusion: Although incidence of HLA-DR2 was not significantly higher in children with aplastic anemia then normal population, response rate to CyA was significantly high in the DR2+ patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Hematology | - |
dc.relation.isPartOf | Korean Journal of Hematology (대한혈액학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 소아 재생불량성빈혈에서 HLA-DR 대립유전자의 발현이 면역억제치료 반응에 미치는 영향 | - |
dc.title.alternative | Response to Immunosuppressive Therapy rind an HIA-DR Allele in Children with Aplastic Anemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | 김길영 | - |
dc.contributor.googleauthor | 조현상 | - |
dc.contributor.googleauthor | 신전수 | - |
dc.contributor.googleauthor | 유철주 | - |
dc.contributor.googleauthor | 양창현 | - |
dc.contributor.googleauthor | 박송희 | - |
dc.contributor.googleauthor | 박세명 | - |
dc.contributor.googleauthor | 김문규 | - |
dc.contributor.googleauthor | 김황민 | - |
dc.contributor.googleauthor | 김세종 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A02144 | - |
dc.relation.journalcode | J02034 | - |
dc.subject.keyword | Aplastic anemia | - |
dc.subject.keyword | HLA-DR | - |
dc.subject.keyword | Immunosuppresive therapy | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | 김세종 | - |
dc.contributor.affiliatedAuthor | 신전수 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 42 | - |
dc.identifier.bibliographicCitation | Korean Journal of Hematology (대한혈액학회지), Vol.34(1) : 36-42, 1999 | - |
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