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흉곽내 악성종양환자에서 Cisplatin 투여시 5-hydroxyindoleacetic Acid (5-HIAA)의 변화

Other Titles
 Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy 
Authors
 양동규  ;  장윤수  ;  김영삼  ;  이준구  ;  박재민  ;  안강현  ;  김세규  ;  정현철  ;  장준  ;  안철민  ;  김성규  ;  이원영 
Citation
 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환), Vol.46(6) : 811-816, 1999 
Journal Title
 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환) 
ISSN
 0378-006 
Issue Date
1999
Keywords
Nausea and vomiting ; Serotonin ; Urinary 5-HIAA ; Cisplatin chemotherapy
Abstract
BACKGROUND: Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin. METHODS: Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis. RESULTS: Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002). CONCLUSION: Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy.
Files in This Item:
T199902677.pdf Download
DOI
10.4046/trd.1999.46.6.811
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Sam(김영삼) ORCID logo https://orcid.org/0000-0001-9656-8482
Ahn, Chul Min(안철민)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
Chang, Joon(장준) ORCID logo https://orcid.org/0000-0003-4542-6841
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174217
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