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흉곽내 악성종양환자에서 Cisplatin 투여시 5-hydroxyindoleacetic Acid (5-HIAA)의 변화
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 안철민 | - |
dc.contributor.author | 장윤수 | - |
dc.contributor.author | 장준 | - |
dc.date.accessioned | 2020-01-23T05:21:37Z | - |
dc.date.available | 2020-01-23T05:21:37Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0378-006 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174217 | - |
dc.description.abstract | BACKGROUND: Nausea and vomiting associated with chemotherapy are common side effects which remain difficult to control. Acute phase nausea and vomiting (0-24 hours after induction of chemotherapy) parallels plasma serotonin release, which explains the effectiveness of 5-HT3 receptor antagonists. Serotonin released from gastrointestinal enterochromaffin cells may mediate chemotherapy-induced emesis. In this study, we analyzed urinary excretion of 5-HIAA, the main metabolite of serotonin. METHODS: Eight men and four women were studied in their cisplatin chemotherapy cycle. Urinary 5-hydroxyindoleacetic aicd (HIAA) levels were determined before and during a 24-hour period under ondansetron prophylaxis. RESULTS: Urinary 5-HIAA excretion for a 24-hour period was increased in all patients after induction of cisplatin (P=0.002). CONCLUSION: Cisplatin chemotherapy is associated with serotonin release in the acute phase. Our finding provides evidence for a relationship between emesis and serotonin following cisplatin chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한결핵 및 호흡기학회 | - |
dc.relation.isPartOf | Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 흉곽내 악성종양환자에서 Cisplatin 투여시 5-hydroxyindoleacetic Acid (5-HIAA)의 변화 | - |
dc.title.alternative | Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion before and during cisplatin chemotherapy in patients with intrathoracic malignancy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 양동규 | - |
dc.contributor.googleauthor | 장윤수 | - |
dc.contributor.googleauthor | 김영삼 | - |
dc.contributor.googleauthor | 이준구 | - |
dc.contributor.googleauthor | 박재민 | - |
dc.contributor.googleauthor | 안강현 | - |
dc.contributor.googleauthor | 김세규 | - |
dc.contributor.googleauthor | 정현철 | - |
dc.contributor.googleauthor | 장준 | - |
dc.contributor.googleauthor | 안철민 | - |
dc.contributor.googleauthor | 김성규 | - |
dc.contributor.googleauthor | 이원영 | - |
dc.identifier.doi | 10.4046/trd.1999.46.6.811 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A05648 | - |
dc.contributor.localId | A03456 | - |
dc.contributor.localId | A03472 | - |
dc.relation.journalcode | J02762 | - |
dc.subject.keyword | Nausea and vomiting | - |
dc.subject.keyword | Serotonin | - |
dc.subject.keyword | Urinary 5-HIAA | - |
dc.subject.keyword | Cisplatin chemotherapy | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 안철민 | - |
dc.contributor.affiliatedAuthor | 장윤수 | - |
dc.contributor.affiliatedAuthor | 장준 | - |
dc.citation.volume | 46 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 811 | - |
dc.citation.endPage | 816 | - |
dc.identifier.bibliographicCitation | Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환), Vol.46(6) : 811-816, 1999 | - |
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