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A new experimental model of obstructive hydrocephalus in the rat: the micro-balloon technique

Authors
 D.-S. Kim  ;  Shizuo Oi  ;  Mitsuru Hidaka  ;  Osamu Sato  ;  Joong-Uhn Choi 
Citation
 Child's Nervous System, Vol.15(5) : 250-255, 1999 
Journal Title
 Child's Nervous System 
ISSN
 0256-7040 
Issue Date
1999
MeSH
Animals ; Catheterization/instrumentation* ; Disease Models, Animal* ; Female ; Hydrocephalus* ; Implants, Experimental ; Kaolin ; Male ; Rats ; Rats, Sprague-Dawley
Abstract
We used three types of specialized micro-balloons 0.7-1.35 mm in outer diameter instead of kaolin to develop a reproducible rat model of hydrocephalus with a low experimental mortality. The micro-balloon was inserted 6 mm deep into the cisterna magna via a burr hole immediately behind the lambda. The angle of introduction was 50 degrees. We also set up kaolin-induced hydrocephalic models in 25 rats as controls. The kaolin model revealed 52% mortality with an 80% induction rate of hydrocephalus, while the balloon model showed 9% mortality with a 60% induction rate. Balloon-induced hydrocephalus was maximal at 1 week and tended to decrease after 2-3 weeks. The pathological findings were not different between the two models. We concluded that the micro-balloon model for hydrocephalus is an easily reproducible model with low experimental mortality.
Full Text
https://link.springer.com/article/10.1007%2Fs003810050385
DOI
10.1007/s003810050385
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Choi, Joong Uhn(최중언)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173681
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