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파킨슨병 환자의 말초 혈액 단핵구에서 D3와 D5 도파민 수용기 mRNA 발현

Other Titles
 D3 and D5 Dopamine Receptor mRNA Expression in Peripheral Blood Mononuclear Cells from Patients with Parkinson’s Disease 
Authors
 최철희  ;  손영호  ;  최선아  ;  박동철  ;  곽용태  ;  최인홍  ;  김진수 
Citation
 Journal of the Korean Neurological Association (대한신경과학회지), Vol.17(3) : 359-364, 1999 
Journal Title
Journal of the Korean Neurological Association(대한신경과학회지)
ISSN
 1225-7044 
Issue Date
1999
Keywords
Parkinson’s disease ; Peripheral blood mononuclear cell ; Dopamine receptor ; messenger RNA ; PCR
Abstract
Background: Among 5 subfamilies of dopamine receptors (DAR), D3 and D5 DAR are expressed on peripheral blood mononuclear cells (PBMC). Recently, those DARs have been reported to change in Parkinson’s disease (PD).
Methods: We measured the DAR mRNA expression in PBMC from 15 PD patients who had never taken antiparkinson medication, and 16 age-matched healthy people by reverse transcription and quantitative competitive polymerase chain reaction. The β-actin mRNA expression was also measured to evaluate the relative expression of DAR mRNA.
Results: The D3 and D5 DAR mRNA expression was not different between patients and controls. In patients, no significant cor-relation was found between DAR mRNA expression in PBMC and clinical variables such as severity and duration of symptoms, and patients’ age.
Conclusions: We confirmed the presence of D3 and D5 DAR in PBMC. However, their mRNA expressions were not influenced by the disease process of PD. J Kor Neurol Ass 17(3):359 ~ 364, 1999
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172616
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