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파킨슨병 환자의 말초 혈액 단핵구에서 D3와 D5 도파민 수용기 mRNA 발현
DC Field | Value | Language |
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dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2019-11-26T00:57:46Z | - |
dc.date.available | 2019-11-26T00:57:46Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1225-7044 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172616 | - |
dc.description.abstract | Background: Among 5 subfamilies of dopamine receptors (DAR), D3 and D5 DAR are expressed on peripheral blood mononuclear cells (PBMC). Recently, those DARs have been reported to change in Parkinson’s disease (PD). Methods: We measured the DAR mRNA expression in PBMC from 15 PD patients who had never taken antiparkinson medication, and 16 age-matched healthy people by reverse transcription and quantitative competitive polymerase chain reaction. The β-actin mRNA expression was also measured to evaluate the relative expression of DAR mRNA. Results: The D3 and D5 DAR mRNA expression was not different between patients and controls. In patients, no significant cor-relation was found between DAR mRNA expression in PBMC and clinical variables such as severity and duration of symptoms, and patients’ age. Conclusions: We confirmed the presence of D3 and D5 DAR in PBMC. However, their mRNA expressions were not influenced by the disease process of PD. J Kor Neurol Ass 17(3):359 ~ 364, 1999 | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한신경과학회 | - |
dc.relation.isPartOf | Journal of the Korean Neurological Association (대한신경과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 파킨슨병 환자의 말초 혈액 단핵구에서 D3와 D5 도파민 수용기 mRNA 발현 | - |
dc.title.alternative | D3 and D5 Dopamine Receptor mRNA Expression in Peripheral Blood Mononuclear Cells from Patients with Parkinson’s Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | 최철희 | - |
dc.contributor.googleauthor | 손영호 | - |
dc.contributor.googleauthor | 최선아 | - |
dc.contributor.googleauthor | 박동철 | - |
dc.contributor.googleauthor | 곽용태 | - |
dc.contributor.googleauthor | 최인홍 | - |
dc.contributor.googleauthor | 김진수 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01836 | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.subject.keyword | Peripheral blood mononuclear cell | - |
dc.subject.keyword | Dopamine receptor | - |
dc.subject.keyword | messenger RNA | - |
dc.subject.keyword | PCR | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | 최인홍 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 359 | - |
dc.citation.endPage | 364 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Neurological Association (대한신경과학회지), Vol.17(3) : 359-364, 1999 | - |
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