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Cyclosporin A가 in vitro에서 조골세포에 미치는 영향

Other Titles
 The effect of Cyclosporin A (CsA) on Osteoblast in vitro 
Authors
 김재우  ;  이현정  ;  강정화  ;  옥승호  ;  최봉규  ;  유윤정  ;  조규성  ;  최성호 
Citation
 Journal of Korean Academy of Periodontology (대한치주과학회지), Vol.30(4) : 747-756, 2000 
Journal Title
 Journal of Korean Academy of Periodontology (대한치주과학회지) 
ISSN
 0250-3352 
Issue Date
2000
MeSH
Alkaline Phosphatase ; Animals ; Bone Diseases, Metabolic ; Bone Remodeling ; Cell Line ; Cell Proliferation ; Collagen ; Cyclosporine* ; Immunosuppression ; Mice ; Organ Transplantation ; Osteoblasts* ; Physiology ; RNA, Messenger ; Transplants
Keywords
Cyclosporin A(CsA) ; Mouse Calvarial Cell ; Osteoblast ; Collagen Synthesis ; Alkaline Phosphatase ; Proliferation
Abstract
Cyclosporin A(CsA) is an immunosuppressive agent widely used for preventing graft rejecting response in organ transplantation. The basic properties of CsA to osteoblast has not been well known yet. A better understanding of the mechanisms of CsA function on bone could provide valuable information regarding basic properties of bone remodeling, pharmacotherapeutic intervention in metabolic bone disease, and the consequences of immunosuppression in bone physiology. The purpose of this study was to investigate the effect of CsA on osteoblast by evaluating parameters of proliferation, collagen synthetic activity, alkaline phosphatase activity, and ALP mRNA expression in mouse calvarial cell. 1. CsA(3㎍/㎖) treated mouse calvarial cell showed statistically significant increase in cell proliferation.(P<0.05) 2. CsA(1, 3㎍/㎖) treated MC3T3 cell line showed statistically significant increase in cell proliferation. 3. The amount of collagen of CsA(3㎍/㎖) treated mouse calvarial cell was decreased statistically significantly. 4. Alkaline phosphatase activity was increased statistically significantly in CsA treated group(1㎍/㎖). 5. mRNA expression of ALP was increased in CsA treated group These results suggest that CsA could affect bone remodeling by modulating proliferation & differentiation of osteoblast.
Files in This Item:
T200003444.pdf Download
DOI
10.5051/jkape.2000.30.4.747
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172387
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