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복합부분발작 환자에서 해마 및 신피질의 대사산물 차이의 비교 : 단일체적 양성자 자기공명분광법을 이용한 짧은 에코시간과 긴 에코시간 기법

Other Titles
 Hippocampal and Neocortical Metabolite Ratio in Patients with Complex Partial Seizure: Short TE and Long TE Techniques Using Single Voxel Proton MR Spectroscopy 
 정진일  ;  김동익  ;  이승익  ;  윤평호  ;  이병인 
 Journal of the Korean Radiologist Society (대한방사선의학회지), Vol.43(2) : 125-130, 2000 
Journal Title
Journal of the Korean Radiologist Society(대한방사선의학회지)
Issue Date
Choline ; Creatine ; Epilepsies, Partial ; Hippocampus ; Humans ; Magnetic Resonance Spectroscopy* ; Malformations of Cortical Development ; Neocortex ; Noise ; Protons* ; Sclerosis ; Seizures* ; Status Epilepticus ; Steam
Magnetic resonance (MR) ; spectroscopy ; Epilepsy Hippocampus
PURPOSE: To compare hippocampal and neocortical metabolite ratios using single-voxel proton MR spectroscopy with different echo times in patients with complex partial seizure. MATERIALS AND METHODS: Using a GE Signa 1.5 T scanner with STEAM and PRESS sequences, automated single voxel proton MRS was used to determine metabolite ratio differences in the hippocampus and neocortex of nine complex partial seizure patients [mesial temporal sclerosis (n=5), status epilepticus (n=1), tumor (n=1), cortical dysplasia (n=1), occipital lobe epilepsy (n=1)]. A total of 20 examinations were performed in the region of the hippocampus (n=17), temporal neocortex (n=1), and parieto-occipital gray matter (n=1). Voxel size range was 5.2 -17.4 cm 3. The calculated creatine (Cr) peak was employed as an internal reference and the relative ratio of N-acetylaspartate (NAA) and choline (Cho) was calculated for both short and long echo times using an automated PROBE/SV (GE Medical Systems) package. Each NAA/Cho ratio obtained using both PRESS and STEAM techniques was compared by means of statistical analysis (paired Student t-test). RESULTS: Using PRESS (long TE, 272 ms), NAA/Cho ratios were successfully calculated in 16 of 20 examinations; in four this was not possible due to noise levels of the Cr and Cho peaks. Using STEAM (short TE, 30 ms) NAA/Cho ratios were successfully calculated in 19 of 20 examinations; in one, the Cho peak could not be measured. Using PRESS and STEAM, mean and standard deviations for the NAA/Cho ratio were 1.22 +/-0.50 and 1.16 +/-0.36, respectively. There were no statistically significant differences in this ratio between the short and long TE method (p <0.01). CONCLUSION: In complex partial seizure patients, no significant metabolite differences were found between short and long echo times of single voxel proton MR spectroscopy. The metabolite ratio at different echo times can be reliably obtained using this simplified and automated PROBE/SV quantitation method.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
Lee, Byung In(이병인)
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