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Restoration of P-glycoprotein function is involved in the increase of Natural Killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals

 Kyung Hee Chang  ;  June Myung Kim  ;  Nae Choon Yoo  ;  Won Ho Kim  ;  Jeon Han Park  ;  In Hong Choi  ;  Hyun Sook Kim  ;  Kyung Won Lee  ;  Young Goo Song  ;  Sung Kwan Hong  ;  Hyo Yeul Kim 
 Yonsei Medical Journal, Vol.41(5) : 600-606, 2000 
Journal Title
 Yonsei Medical Journal 
Issue Date
ATP-Binding Cassette, Sub-Family B, Member 1/physiology* ; HIV Infections/pathology ; HIV Infections/physiopathology* ; Humans ; Interleukin-15/pharmacology* ; Killer Cells, Natural/drug effects* ; Killer Cells, Natural/physiology* ; Recombinant Proteins/pharmacology
Interleukin-15 ; NK cells ; NK activity ; HIV ; P-glycoprotein
A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1alpha (MIP-1alpha), macrophage chemotactic protein-1alpha (MCP-1alpha) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, June Myung(김준명)
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
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