Cited 7 times in
Restoration of P-glycoprotein function is involved in the increase of Natural Killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 김준명 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2019-11-11T05:27:37Z | - |
dc.date.available | 2019-11-11T05:27:37Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171898 | - |
dc.description.abstract | A depressed level of natural killer (NK) activity is one of the various immunologic abnormalities in human immunodeficiency virus (HIV) infection. Interleukin-15 (IL-15), an immunotherapeutic candidate in HIV infection, increases NK activity and induces the excretion of CC-chemokines from divergent immune cells, but the mechanisms of NK activity enhancement by IL-15 stimulation is not clearly established in HIV infection. This study examined whether CC-chemokines, which are known to increase NK activity, are secreted adequately in HIV-infected individuals, and also investigated whether P-glycoprotein is involved in NK activity enhancement after IL-15 administration. NK activity increased with IL-15 stimulation in NK cells of HIV-infected individuals, as it does in normal NK cells. IL-15 stimulates NK cells to secrete CC-chemokines, such as, macrophage inflammatory protein-1alpha (MIP-1alpha), macrophage chemotactic protein-1alpha (MCP-1alpha) and regulated upon activation, normal T cells expressed and secreted (RANTES) in both HIV-infected individuals and controls with no significant difference. P-glycoprotein expression and function is decreased in HIV-infected individuals and restored only in NK cells of HIV-infected individuals after IL-15 stimulation. P-glycoprotein may play a role in the mechanism of increased NK cell activity in HIV-infected individuals after IL-15 stimulation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | Yonsei Medical Journal | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | ATP-Binding Cassette, Sub-Family B, Member 1/physiology* | - |
dc.subject.MESH | HIV Infections/pathology | - |
dc.subject.MESH | HIV Infections/physiopathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-15/pharmacology* | - |
dc.subject.MESH | Killer Cells, Natural/drug effects* | - |
dc.subject.MESH | Killer Cells, Natural/physiology* | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.title | Restoration of P-glycoprotein function is involved in the increase of Natural Killer activity with exogenous interleukin-15 in human immunodeficiency virus-infected individuals | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyung Hee Chang | - |
dc.contributor.googleauthor | June Myung Kim | - |
dc.contributor.googleauthor | Nae Choon Yoo | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | In Hong Choi | - |
dc.contributor.googleauthor | Hyun Sook Kim | - |
dc.contributor.googleauthor | Kyung Won Lee | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.contributor.googleauthor | Sung Kwan Hong | - |
dc.contributor.googleauthor | Hyo Yeul Kim | - |
dc.identifier.doi | 10.3349/ymj.2000.41.5.600 | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A00953 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 11079620 | - |
dc.subject.keyword | Interleukin-15 | - |
dc.subject.keyword | NK cells | - |
dc.subject.keyword | NK activity | - |
dc.subject.keyword | HIV | - |
dc.subject.keyword | P-glycoprotein | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | 김원호 | - |
dc.contributor.affiliatedAuthor | 김준명 | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.contributor.affiliatedAuthor | 송영구 | - |
dc.contributor.affiliatedAuthor | 이경원 | - |
dc.contributor.affiliatedAuthor | 최인홍 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 600 | - |
dc.citation.endPage | 606 | - |
dc.identifier.bibliographicCitation | Yonsei Medical Journal, Vol.41(5) : 600-606, 2000 | - |
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