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Diversity of the p70 killer inhibitory receptor (KIR3D) family members in a single individual

Authors
 DaeHo Kwon  ;  Yong-Joon Chwae  ;  In Hong Choi  ;  Jeon Han Park  ;  Se Jong Kim  ;  Jong Sun Kim 
Citation
 Molecules and Cells, Vol.10(1) : 54-60, 2000 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2000
MeSH
Alternative Splicing ; Amino Acid Sequence ; Cloning, Molecular ; DNA, Complementary/chemistry ; DNA, Complementary/genetics* ; Genetic Variation ; Humans ; Killer Cells, Natural/metabolism* ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Molecular Sequence Data ; Multigene Family/genetics* ; Protein Isoforms/genetics ; Receptors, Immunologic/genetics* ; Receptors, KIR ; Receptors, KIR2DL3 ; Receptors, KIR2DL4 ; Receptors, KIR3DL1 ; Receptors, KIR3DL2 ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid
Keywords
Alternative Splicing ; NK Cells ; p70 KIR ; Polymorphism ; Receptor Repertoire
Abstract
NK cells and some T cells express members of a multigenic family of killer cell inhibitory receptors (KIRs) including p70 KIR (KIR3DL) and p58 KIR (KIR2DL) family that recognize polymorphic class I MHC molecules on target cells and transmit an inhibitory signal to prevent killer cell-mediated cytoxicity. The cDNA sequences of p70 KIR family members reported so far suggest that the p70 KIR gene consists of a multigene complex and that each gene may exhibit certain degrees of polymorphism. However, it is not clear how diverse the repertoire of the p70 KIR family is, particularly in a single individual. To address this question in more detail and to determine some indication as to the origin of the diversity, we cloned p70 KIR cDNAs from a single individual. We identified nine new KIRs that are different from the previously reported ones. A comparison of the amino acid sequences with published sequences of p70 KIRs showed that two clones belonged to the KIR3DL1 family, five clones belonged to the KIR3DL2 family, one clone belonged to the KIR2DL4 family, and one clone appeared to be an alternatively spliced form of p70 KIR. These results suggested that the repertoire of p70 KIR family members in a single individual is highly diverse. It is not clear how the diverse receptors are generated in a single individual, but a comparison of amino acid sequences of p70 KIR family members suggested that some of them may be encoded by distinct genes or their alleles, while others may be generated by a recombination mechanism and/or an alternative splicing mechanism at the maturation of the mRNA transcripts.
Files in This Item:
T200003094.pdf Download
DOI
10.1007/s10059-000-0054-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Jong(김세종)
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171806
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