Cited 7 times in
Diversity of the p70 killer inhibitory receptor (KIR3D) family members in a single individual
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세종 | - |
dc.contributor.author | 김종선 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2019-11-11T05:21:25Z | - |
dc.date.available | 2019-11-11T05:21:25Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171806 | - |
dc.description.abstract | NK cells and some T cells express members of a multigenic family of killer cell inhibitory receptors (KIRs) including p70 KIR (KIR3DL) and p58 KIR (KIR2DL) family that recognize polymorphic class I MHC molecules on target cells and transmit an inhibitory signal to prevent killer cell-mediated cytoxicity. The cDNA sequences of p70 KIR family members reported so far suggest that the p70 KIR gene consists of a multigene complex and that each gene may exhibit certain degrees of polymorphism. However, it is not clear how diverse the repertoire of the p70 KIR family is, particularly in a single individual. To address this question in more detail and to determine some indication as to the origin of the diversity, we cloned p70 KIR cDNAs from a single individual. We identified nine new KIRs that are different from the previously reported ones. A comparison of the amino acid sequences with published sequences of p70 KIRs showed that two clones belonged to the KIR3DL1 family, five clones belonged to the KIR3DL2 family, one clone belonged to the KIR2DL4 family, and one clone appeared to be an alternatively spliced form of p70 KIR. These results suggested that the repertoire of p70 KIR family members in a single individual is highly diverse. It is not clear how the diverse receptors are generated in a single individual, but a comparison of amino acid sequences of p70 KIR family members suggested that some of them may be encoded by distinct genes or their alleles, while others may be generated by a recombination mechanism and/or an alternative splicing mechanism at the maturation of the mRNA transcripts. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society for Molecular and Cellular Biology | - |
dc.relation.isPartOf | Molecules and Cells | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alternative Splicing | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Cloning, Molecular | - |
dc.subject.MESH | DNA, Complementary/chemistry | - |
dc.subject.MESH | DNA, Complementary/genetics* | - |
dc.subject.MESH | Genetic Variation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Killer Cells, Natural/metabolism* | - |
dc.subject.MESH | Leukocytes, Mononuclear/cytology | - |
dc.subject.MESH | Leukocytes, Mononuclear/metabolism | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Multigene Family/genetics* | - |
dc.subject.MESH | Protein Isoforms/genetics | - |
dc.subject.MESH | Receptors, Immunologic/genetics* | - |
dc.subject.MESH | Receptors, KIR | - |
dc.subject.MESH | Receptors, KIR2DL3 | - |
dc.subject.MESH | Receptors, KIR2DL4 | - |
dc.subject.MESH | Receptors, KIR3DL1 | - |
dc.subject.MESH | Receptors, KIR3DL2 | - |
dc.subject.MESH | Sequence Alignment | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Sequence Homology, Amino Acid | - |
dc.title | Diversity of the p70 killer inhibitory receptor (KIR3D) family members in a single individual | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | DaeHo Kwon | - |
dc.contributor.googleauthor | Yong-Joon Chwae | - |
dc.contributor.googleauthor | In Hong Choi | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.googleauthor | Jong Sun Kim | - |
dc.identifier.doi | 10.1007/s10059-000-0054-0 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A00921 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 10774747 | - |
dc.subject.keyword | Alternative Splicing | - |
dc.subject.keyword | NK Cells | - |
dc.subject.keyword | p70 KIR | - |
dc.subject.keyword | Polymorphism | - |
dc.subject.keyword | Receptor Repertoire | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | 김세종 | - |
dc.contributor.affiliatedAuthor | 김종선 | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.contributor.affiliatedAuthor | 최인홍 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.citation.endPage | 60 | - |
dc.identifier.bibliographicCitation | Molecules and Cells, Vol.10(1) : 54-60, 2000 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.