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Expression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages.

Authors
 Eui Cheol Shin  ;  Seong Eun Cho  ;  Dong-Kee Lee  ;  Man-Wook Hurl  ;  Seung R. Paik  ;  Jeon Han Park  ;  Jongsun Kim 
Citation
 Molecules and Cells, Vol.10(1) : 65-70, 2000 
Journal Title
 Molecules and Cells 
ISSN
 1016-8478 
Issue Date
2000
MeSH
Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Blotting, Western ; Drosophila/embryology ; Drosophila/genetics* ; Embryo, Nonmammalian/metabolism ; Embryonic Development ; Gene Expression ; Gene Expression Regulation, Developmental ; Humans ; Jurkat Cells ; K562 Cells ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism* ; Monocytes/cytology ; Monocytes/metabolism ; Nerve Tissue Proteins/genetics* ; RNA/genetics ; RNA/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Synucleins ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism ; alpha-Synuclein
Keywords
Development ; Gene Expression ; NACP ; Neurodegenerative Disease ; Synuclein
Abstract
Alpha-synuclein, a presynaptic protein of the central nervous system, has been implicated in the synaptic events such as neuronal plasticity during development and learning, and neuronal degeneration under pathological conditions. As an effort to understand the biological function of alpha-synuclein, we examined the expression patterns of alpha-synuclein in various human hematopoietic cells, and in Drosophila at different developmental stages. The alpha-synuclein was ubiquitously expressed in all the tested hematopoietic cells including T cells, B cells, NK cells, and monocytes, as well as in the lymphoma cell lines, Jurkat and K562. A potential alpha-synuclein homologue was also expressed in Drosophila, and its expression appeared to be temporally and spatially regulated during development. Our data suggest that alpha-synuclein may function in invertebrates as well as in vertebrates and its function may not be restricted to the neuron.
Files in This Item:
T200002286.pdf Download
DOI
10.1007/s10059-000-0065-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Sun(김종선) ORCID logo https://orcid.org/0000-0002-3149-669X
Park, Jeon Han(박전한) ORCID logo https://orcid.org/0000-0001-9604-3205
Hur, Man Wook(허만욱) ORCID logo https://orcid.org/0000-0002-3416-1334
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171805
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