Cited 83 times in

Expression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages.

DC Field Value Language
dc.contributor.author김종선-
dc.contributor.author박전한-
dc.contributor.author허만욱-
dc.date.accessioned2019-11-11T05:21:18Z-
dc.date.available2019-11-11T05:21:18Z-
dc.date.issued2000-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171805-
dc.description.abstractAlpha-synuclein, a presynaptic protein of the central nervous system, has been implicated in the synaptic events such as neuronal plasticity during development and learning, and neuronal degeneration under pathological conditions. As an effort to understand the biological function of alpha-synuclein, we examined the expression patterns of alpha-synuclein in various human hematopoietic cells, and in Drosophila at different developmental stages. The alpha-synuclein was ubiquitously expressed in all the tested hematopoietic cells including T cells, B cells, NK cells, and monocytes, as well as in the lymphoma cell lines, Jurkat and K562. A potential alpha-synuclein homologue was also expressed in Drosophila, and its expression appeared to be temporally and spatially regulated during development. Our data suggest that alpha-synuclein may function in invertebrates as well as in vertebrates and its function may not be restricted to the neuron.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Molecular and Cellular Biology-
dc.relation.isPartOfMolecules and Cells-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHB-Lymphocytes/cytology-
dc.subject.MESHB-Lymphocytes/metabolism-
dc.subject.MESHBlotting, Western-
dc.subject.MESHDrosophila/embryology-
dc.subject.MESHDrosophila/genetics*-
dc.subject.MESHEmbryo, Nonmammalian/metabolism-
dc.subject.MESHEmbryonic Development-
dc.subject.MESHGene Expression-
dc.subject.MESHGene Expression Regulation, Developmental-
dc.subject.MESHHumans-
dc.subject.MESHJurkat Cells-
dc.subject.MESHK562 Cells-
dc.subject.MESHKiller Cells, Natural/cytology-
dc.subject.MESHKiller Cells, Natural/metabolism-
dc.subject.MESHLeukocytes, Mononuclear/cytology-
dc.subject.MESHLeukocytes, Mononuclear/metabolism*-
dc.subject.MESHMonocytes/cytology-
dc.subject.MESHMonocytes/metabolism-
dc.subject.MESHNerve Tissue Proteins/genetics*-
dc.subject.MESHRNA/genetics-
dc.subject.MESHRNA/metabolism-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSynucleins-
dc.subject.MESHT-Lymphocytes/cytology-
dc.subject.MESHT-Lymphocytes/metabolism-
dc.subject.MESHalpha-Synuclein-
dc.titleExpression patterns of alpha-synuclein in human hematopoietic cells and in Drosophila at different developmental stages.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학교실)-
dc.contributor.googleauthorEui Cheol Shin-
dc.contributor.googleauthorSeong Eun Cho-
dc.contributor.googleauthorDong-Kee Lee-
dc.contributor.googleauthorMan-Wook Hurl-
dc.contributor.googleauthorSeung R. Paik-
dc.contributor.googleauthorJeon Han Park-
dc.contributor.googleauthorJongsun Kim-
dc.identifier.doi10.1007/s10059-000-0065-x-
dc.contributor.localIdA00921-
dc.contributor.localIdA01641-
dc.contributor.localIdA04350-
dc.relation.journalcodeJ02273-
dc.identifier.eissn0219-1032-
dc.identifier.pmid10774749-
dc.subject.keywordDevelopment-
dc.subject.keywordGene Expression-
dc.subject.keywordNACP-
dc.subject.keywordNeurodegenerative Disease-
dc.subject.keywordSynuclein-
dc.contributor.alternativeNameKim, Jong Sun-
dc.contributor.affiliatedAuthor김종선-
dc.contributor.affiliatedAuthor박전한-
dc.contributor.affiliatedAuthor허만욱-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage65-
dc.citation.endPage70-
dc.identifier.bibliographicCitationMolecules and Cells, Vol.10(1) : 65-70, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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