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Biphasic effects of dithiocarbamates on the activity of nuclear factor-κB

Authors
 Chul Hoon Kim  ;  Joo Hee Kim  ;  Seok Jun Moon  ;  Chung Y Hsu  ;  Jeong Taeg Seo  ;  Young Soo Ahn 
Citation
 European Journal of Pharmacology, Vol.392(3) : 133-136, 2000 
Journal Title
 European Journal of Pharmacology 
ISSN
 0014-2999 
Issue Date
2000
MeSH
Animals ; Cattle ; Cells, Cultured ; Cerebral Cortex/blood supply ; Ditiocarb/pharmacology* ; Dose-Response Relationship, Drug ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; NF-kappa B/antagonists & inhibitors* ; Pyrrolidines/pharmacology* ; Thiocarbamates/pharmacology* ; Zinc/metabolism ; Zinc/pharmacokinetics
Keywords
Cerebral endothelial cell ; (Bovine) ; Dithiocarbamate ; NF-κB (nuclear factor-κB) ; Zn2+
Abstract
Dithiocarbamates are well-known antioxidants and nuclear factor-kappaB (NF-kappaB) inhibitors. Recently, they have been characterized as zinc ionophores. Concentration-dependent biphasic effects of dithiocarbamates on NF-kappaB activity have been widely reported. We studied the mechanism of this phenomenon in relation to Zn(2+) influx. Two dithiocarbamates, pyrrolidine dithiocarbamate and diethyldithiocarbamate, showed concentration-dependent biphasic effects in inhibiting NF-kappaB activation in cerebral endothelial cells. These unique effects of dithiocarbamates on NF-kappaB were tightly linked to their ability to elevate intracellular Zn(2+)500 microM), dithiocarbamates started to lose their ability to promote Zn(2+) influx and to inhibit NF-kappaB activation. These results might provide insight into the appropriate use of dithiocarbamates in various disorders.
Full Text
https://www.sciencedirect.com/science/article/pii/S0014299900001096
DOI
10.1016/S0014-2999(00)00109-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
Ahn, Young Soo(안영수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171630
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