Cited 33 times in
Biphasic effects of dithiocarbamates on the activity of nuclear factor-κB
DC Field | Value | Language |
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dc.contributor.author | 김철훈 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 서정택 | - |
dc.contributor.author | 안영수 | - |
dc.date.accessioned | 2019-11-11T05:07:29Z | - |
dc.date.available | 2019-11-11T05:07:29Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171630 | - |
dc.description.abstract | Dithiocarbamates are well-known antioxidants and nuclear factor-kappaB (NF-kappaB) inhibitors. Recently, they have been characterized as zinc ionophores. Concentration-dependent biphasic effects of dithiocarbamates on NF-kappaB activity have been widely reported. We studied the mechanism of this phenomenon in relation to Zn(2+) influx. Two dithiocarbamates, pyrrolidine dithiocarbamate and diethyldithiocarbamate, showed concentration-dependent biphasic effects in inhibiting NF-kappaB activation in cerebral endothelial cells. These unique effects of dithiocarbamates on NF-kappaB were tightly linked to their ability to elevate intracellular Zn(2+)500 microM), dithiocarbamates started to lose their ability to promote Zn(2+) influx and to inhibit NF-kappaB activation. These results might provide insight into the appropriate use of dithiocarbamates in various disorders. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | European Journal of Pharmacology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cattle | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cerebral Cortex/blood supply | - |
dc.subject.MESH | Ditiocarb/pharmacology* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Endothelium, Vascular/cytology | - |
dc.subject.MESH | Endothelium, Vascular/drug effects | - |
dc.subject.MESH | Endothelium, Vascular/metabolism | - |
dc.subject.MESH | NF-kappa B/antagonists & inhibitors* | - |
dc.subject.MESH | Pyrrolidines/pharmacology* | - |
dc.subject.MESH | Thiocarbamates/pharmacology* | - |
dc.subject.MESH | Zinc/metabolism | - |
dc.subject.MESH | Zinc/pharmacokinetics | - |
dc.title | Biphasic effects of dithiocarbamates on the activity of nuclear factor-κB | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Chul Hoon Kim | - |
dc.contributor.googleauthor | Joo Hee Kim | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.contributor.googleauthor | Chung Y Hsu | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.contributor.googleauthor | Young Soo Ahn | - |
dc.identifier.doi | 10.1016/S0014-2999(00)00109-6 | - |
dc.contributor.localId | A01057 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A02246 | - |
dc.relation.journalcode | J00842 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.identifier.pmid | 10762665 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0014299900001096 | - |
dc.subject.keyword | Cerebral endothelial cell | - |
dc.subject.keyword | (Bovine) | - |
dc.subject.keyword | Dithiocarbamate | - |
dc.subject.keyword | NF-κB (nuclear factor-κB) | - |
dc.subject.keyword | Zn2+ | - |
dc.contributor.alternativeName | Kim, Chul Hoon | - |
dc.contributor.affiliatedAuthor | 김철훈 | - |
dc.contributor.affiliatedAuthor | 문석준 | - |
dc.contributor.affiliatedAuthor | 서정택 | - |
dc.contributor.affiliatedAuthor | 안영수 | - |
dc.citation.volume | 392 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 133 | - |
dc.citation.endPage | 136 | - |
dc.identifier.bibliographicCitation | European Journal of Pharmacology, Vol.392(3) : 133-136, 2000 | - |
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